(Q34575325)

3 August 2017

1 reference

title

Chemokine receptors: multifaceted therapeutic targets (English)

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CXCR chemokine receptor binding

3 August 2017

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0045236

CXCR2 chemokine receptor binding

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0045238

CXCR1 chemokine receptor binding

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Gene Ontology release 2020-05-02

Amanda E I Proudfoot

1

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3 August 2017

1 February 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

106-115

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3 August 2017

2

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Chemokines--chemotactic cytokines that mediate inflammation

3 August 2017

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Chemokines: a new classification system and their role in immunity

31 March 2020

1 reference

Etanercept (Enbrel): update on therapeutic use

31 March 2020

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Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

31 March 2020

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Marimastat: the clinical development of a matrix metalloproteinase inhibitor

31 March 2020

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Interfering with chemokine networks--the hope for new therapeutics

31 March 2020

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Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

31 March 2020

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

31 March 2020

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

31 March 2020

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

31 March 2020

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Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization

31 March 2020

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Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties

31 March 2020

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Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes

31 March 2020

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Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation

31 March 2020

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The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis

31 March 2020

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Lipids on the move: phosphoinositide 3-kinases in leukocyte function

31 March 2020

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Signaling by the cytokine receptor superfamily

31 March 2020

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RANTES and MIP-1alpha activate stats in T cells

31 March 2020

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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

31 March 2020

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Differential activation of CC chemokine receptors by AOP-RANTES

31 March 2020

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CC chemokine receptor-3 undergoes prolonged ligand-induced internalization

31 March 2020

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Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses

31 March 2020

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Inflammation and cancer: back to Virchow?

31 March 2020

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Identification and characterization of an inhibitor of haemopoietic stem cell proliferation.

31 March 2020

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Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality

31 March 2020

1 reference

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

31 March 2020

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Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids

31 March 2020

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Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge

31 March 2020

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RANTES chemokine expression in diseased and normal human tissues

31 March 2020

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RANTES chemokine expression in cell-mediated transplant rejection of the kidney.

31 March 2020

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Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

31 March 2020

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CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions

31 March 2020

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A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.

31 March 2020

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Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SF

31 March 2020

1 reference

Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.

31 March 2020

1 reference

The −403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma

31 March 2020

1 reference

Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity

31 March 2020

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Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice

31 March 2020

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MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation

31 March 2020

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CXCL10 (IFN-gamma-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis.

31 March 2020

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The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness

31 March 2020

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Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia

31 March 2020

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Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1alpha and monocyte chemotactic protein-1

31 March 2020

1 reference

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor

31 March 2020

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Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection

31 March 2020

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Requirement of the chemokine receptor CXCR3 for acute allograft rejection

31 March 2020

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Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the inte

31 March 2020

1 reference

Delta 32 mutation of the chemokine-receptor 5 gene in inflammatory bowel disease

31 March 2020

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A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

31 March 2020

1 reference

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

31 March 2020

1 reference

Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1

31 March 2020

1 reference

Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues

31 March 2020

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RANTES and MCP-3 antagonists bind multiple chemokine receptors

31 March 2020

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A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer

31 March 2020

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An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model

31 March 2020

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Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors

31 March 2020

1 reference

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

31 March 2020

1 reference

Endocytosis and recycling of the HIV coreceptor CCR5

31 March 2020

1 reference

Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice

31 March 2020

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RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis

31 March 2020

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The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.

31 March 2020

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Differential binding of chemokines to glycosaminoglycan subpopulations

31 March 2020

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Neutrophil attractant/activation protein-1 (interleukin-8) induces in vitro neutrophil migration by haptotactic mechanism

31 March 2020

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Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

31 March 2020

1 reference

Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus

31 March 2020

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Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression

31 March 2020

1 reference

Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states.

31 March 2020

1 reference

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

31 March 2020

1 reference

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

31 March 2020

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Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor

31 March 2020

1 reference

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

31 March 2020

1 reference

Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application

31 March 2020

1 reference

A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.

31 March 2020

1 reference

Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor.

31 March 2020

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

31 March 2020

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CC chemokine receptor 5 and renal-transplant survival

31 March 2020

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Dual effect of CCR5 Δ32 gene deletion in HIV-1-infected patients

31 March 2020

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CCR5 Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

31 March 2020

1 reference

Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

1 reference

Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

31 March 2020

1 reference

Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.

31 March 2020

1 reference

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis.

31 March 2020

1 reference

A human T cell-specific molecule is a member of a new gene family

31 March 2020

1 reference

12 December 2020

Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation

1 reference

12 December 2020

Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.

1 reference

12 December 2020

HIV entry and tropism: the chemokine receptor connection.

1 reference

12 December 2020

Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities

1 reference

12 December 2020

Clearance of human platelet factor 4 by liver and kidney: its alteration by heparin

1 reference

12 December 2020

Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats.

1 reference

12 December 2020

CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone.

1 reference

12 December 2020

1 reference

12 December 2020

Molecular and biochemical characterization of a novel gamma-interferon-inducible protein

1 reference

12 December 2020

Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI722

1 reference

3 August 2017

1 reference

PubMed ID

11910892