(Q34575806)

English

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

based on heuristic

inferred from title

author name string

Sadim Jawhar

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Oliver Wirths

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Stephan Schilling

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Sigrid Graubner

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Hans-Ulrich Demuth

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Thomas A Bayer

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

10 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

3 August 2017

286

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Europe PubMed Central

PubMed publication ID

3 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

4454-4460

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3039372/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

1 reference

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

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Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

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Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

1 reference

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Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

1 reference

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

1 reference

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Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

1 reference

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

1 reference

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1 reference

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Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

1 reference

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The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

1 reference

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1 reference

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N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits.

1 reference

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Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

1 reference

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Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

1 reference

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7 July 2018

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

1 reference

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1 reference

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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1 reference

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

1 reference

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21 January 2018

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

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Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.185819

21 January 2018

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039372

27 October 2018

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21148560

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21148560

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.185819

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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