(Q34576179)

3 August 2017

1 reference

title

Discovery of anti-TB agents that target the cell-division protein FtsZ. (English)

1 reference

3 August 2017

5

Richard A Slayden

1 reference

3 August 2017

Iwao Ojima

6

0 references

Peter J. Tonge

object named as

Peter J Tonge

4

0 references

author name string

Kunal Kumar

1

1 reference

PubMed ID

21339840

3 August 2017

Divya Awasthi

2

1 reference

PubMed ID

21339840

3 August 2017

William T Berger

3

1 reference

3 August 2017

1 August 2010

1 reference

Future Medicinal Chemistry

3 August 2017

1 reference

3 August 2017

2

1 reference

3 August 2017

8

1 reference

3 August 2017

1305-1323

1 reference

Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Simple modeling of FtsZ polymers on flat and curved surfaces: correlation with experimental in vitro observations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

System-level design of bacterial cell cycle control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Condensation of FtsZ filaments can drive bacterial cell division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

SepF increases the assembly and bundling of FtsZ polymers and stabilizes FtsZ protofilaments by binding along its length

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Structural insights into the conformational variability of FtsZ

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Septum enlightenment: assembly of bacterial division proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

N-terminal stathmin-like peptides bind tubulin and impede microtubule assembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

FtsZ and the division of prokaryotic cells and organelles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Diverse paths to midcell: assembly of the bacterial cell division machinery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Increasing complexity of the bacterial cytoskeleton

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

FtsZ exhibits rapid movement and oscillation waves in helix-like patterns in Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Assembly Dynamics of the Bacterial Cell Division Protein FtsZ: Poised at the Edge of Stability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

7 July 2018

Cytokinesis in bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

The Min system is not required for precise placement of the midcell Z ring in Bacillus subtilis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

The chemistry of taxol and related taxoids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Assembly of an FtsZ mutant deficient in GTPase activity has implications for FtsZ assembly and the role of the Z ring in cell division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Activation of cell division protein FtsZ. Control of switch loop T3 conformation by the nucleotide gamma-phosphate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Issues facing TB control (7). Multiple drug-resistant tuberculosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Solution structure of ZipA, a crucial component of Escherichia coli cell division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Slow polymerization of Mycobacterium tuberculosis FtsZ

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Tubulin-like protofilaments in Ca2+-induced FtsZ sheets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Bacterial cell division and the Z ring

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

4',6-Diamidino-2-phenylindole, a fluorescent probe for tubulin and microtubules.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Antimicrobial action of sanguinarine.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Tuberculosis: commentary on a reemergent killer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Antibacterial activity of totarol and its potentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Antimicrobial activities of constituents of Uvaria chamae

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039483

Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches

7 July 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

The chromosome partitioning protein, ParB, is required for cytokinesis in Caulobacter crescentus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

The order of the ring: assembly of Escherichia coli cell division components.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Polymerization of nucleotide-free, GDP- and GTP-bound cell division protein FtsZ: GDP makes the difference

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

(+)-Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

GTP hydrolysis of cell division protein FtsZ: evidence that the active site is formed by the association of monomers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Antimicrobial constituents from goldenseal (the Rhizomes of Hydrastis canadensis) against selected oral pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Berberine targets assembly of Escherichia coli cell division protein FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

The stathmin-derived I19L peptide interacts with FtsZ and alters its bundling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Fluorescence resonance energy transfer and molecular modeling studies on 4',6-diamidino-2-phenylindole (DAPI) complexes with tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Interaction between the C-terminal peptides of tubulin and tubulin S detected with the fluorescent probe 4',6-diamidino-2-phenylindole.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

4',6-Diamidino-2-phenylindole (DAPI) induces bundling of Escherichia coli FtsZ polymers inhibiting the GTPase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis inMycobacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Tubulin Secondary Structure Analysis, Limited Proteolysis Sites, and Homology to FtsZ†

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

The essential bacterial cell-division protein FtsZ is a GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

New taxanes as highly efficient reversal agents for multi-drug resistance in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.220

Genetic analysis of the Escherichia coli FtsZ.ZipA interaction in the yeast two-hybrid system. Characterization of FtsZ residues essential for the interactions with ZipA and with FtsA

21 January 2018

1 reference

12 December 2020

Bacterial cell division

1 reference

12 December 2020

Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis

1 reference

12 December 2020

Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ

1 reference

12 December 2020

Apparent differences in antimicrobial susceptibility as a consequence of national guidelines

1 reference

12 December 2020

Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo

1 reference

12 December 2020

Identifiers

DOI

10.4155/FMC.10.220

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

PubMed ID

21339840