(Q34578769)

3 August 2017

1 reference

title

Mouse models of Alzheimer's disease: a quest for plaques and tangles (English)

1 reference

3 August 2017

0 references

James A Richardson

1

1 reference

PubMed ID

11917160

3 August 2017

Dennis K Burns

series ordinal

2

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3 August 2017

1 January 2002

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3 August 2017

1 reference

3 August 2017

43

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3 August 2017

2

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3 August 2017

89-99

1 reference

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

3 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

The tauopathies: toward an experimental animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Transgenic mice expressing APP-C100 in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Formation of beta-amyloid protein deposits in brains of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.2.89

21 January 2018

Identifiers

DOI

10.1093/ILAR.43.2.89

1 reference

3 August 2017

1 reference

PubMed ID

11917160