(Q34583702)

3 August 2017

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain (English)

1 reference

3 August 2017

Gareth J Morgan

4

0 references

Christina B Cooley

object named as

Christina B Cooley

1

0 references

Lars Plate

object named as

Lars Plate

3

0 references

Jeffery W. Kelly

6

object named as

Jeffery W Kelly

1 reference

3 August 2017

Lisa M Ryno

2

1 reference

3 August 2017

John D Hulleman

5

1 reference

3 August 2017

R Luke Wiseman

7

1 reference

3 August 2017

language of work or name

English

0 references

publication date

25 August 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

1 reference

3 August 2017

111

1 reference

3 August 2017

36

1 reference

3 August 2017

13046-13051

1 reference

describes a project that uses

3 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4246986/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

7 July 2018

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A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion

7 July 2018

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Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation

7 July 2018

1 reference

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Translational attenuation differentially alters the fate of disease-associated fibulin proteins

7 July 2018

1 reference

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

7 July 2018

1 reference

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The impact of the unfolded protein response on human disease

7 July 2018

1 reference

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A molecular history of the amyloidoses

7 July 2018

1 reference

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Road to ruin: targeting proteins for degradation in the endoplasmic reticulum

7 July 2018

1 reference

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The unfolded protein response: from stress pathway to homeostatic regulation

7 July 2018

1 reference

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Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis

7 July 2018

1 reference

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Molecular chaperones in protein folding and proteostasis

7 July 2018

1 reference

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Amyloidosis: pathogenesis and new therapeutic options.

7 July 2018

1 reference

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Monitoring and manipulating mammalian unfolded protein response

7 July 2018

1 reference

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Systemic light-chain amyloidosis: advances in diagnosis, prognosis, and therapy

7 July 2018

1 reference

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The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain

7 July 2018

1 reference

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7 July 2018

1 reference

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Biological and chemical approaches to diseases of proteostasis deficiency

7 July 2018

1 reference

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AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences

7 July 2018

1 reference

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Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

7 July 2018

1 reference

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Adapting proteostasis for disease intervention

7 July 2018

1 reference

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Inhibition of p97-dependent protein degradation by Eeyarestatin I

7 July 2018

1 reference

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A highly sensitive assay for monitoring the secretory pathway and ER stress

7 July 2018

1 reference

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Managing and exploiting stress in the antibody factory.

7 July 2018

1 reference

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The biological and chemical basis for tissue-selective amyloid disease

7 July 2018

1 reference

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Induction of endoplasmic reticulum stress by ellipticine plant alkaloids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Autologous stem cell transplantation for primary systemic amyloidosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Synthesis and assembly of immunoglobulins by malignant human plasmacytes. I. Myelomas producing gamma-chains and light chains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Treatment of "primary" renal amyloidosis with melphalan.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Induction in mice of human light-chain-associated amyloidosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246986

Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

Regulation of transcription and translation by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

High-Dose Melphalan versus Melphalan plus Dexamethasone for AL Amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

Efficacy and safety of once-weekly and twice-weekly bortezomib in patients with relapsed systemic AL amyloidosis: results of a phase 1/2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406050111

Autophagy: an ER protein quality control process

21 January 2018

1 reference

12 December 2020

Thermodynamic instability of human lambda 6 light chains: correlation with fibrillogenicity

1 reference

12 December 2020

The stressful road to antibody secretion

1 reference

12 December 2020

Time course of labeling of light and heavy chains of immunoglobulin G and the turnover of the free light-chain intermediates

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1406050111

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference