(Q34588663)

3 August 2017

1 reference

title

Is pharmacological prevention of Alzheimer's a realistic goal? (English)

1 reference

3 August 2017

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Peter P Zandi

1

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3 August 2017

John C S Breitner

series ordinal

2

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3 August 2017

James C Anthony

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

1 April 2002

1 reference

Expert Opinion on Pharmacotherapy

3 August 2017

published in

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3 August 2017

volume

3

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3 August 2017

issue

4

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3 August 2017

page(s)

365-380

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The increasing prevalence of mental disorders: A pandemic threat

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

21 January 2018

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21 January 2018

Cyclooxygenases 1 and 2

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Inflammation and Alzheimer's disease: relationships between pathogenic mechanisms and clinical expression.

21 January 2018

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

21 January 2018

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Microglia and the immune pathology of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Inflammation and Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Molecular mechanisms associated with long-term consolidation of the NMDA signals

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Pyramidal nerve cell loss in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain.

21 January 2018

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Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

21 January 2018

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beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

21 January 2018

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Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro

21 January 2018

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beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Alzheimer's disease: a study of epidemiological aspects.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A case-control study of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Rheumatoid arthritis and senile dementia of the Alzheimer's type.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Anti-inflammatory drugs and Alzheimer disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Rheumatoid arthritis and susceptibility to Alzheimer's disease.

21 January 2018

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Alzheimer's disease and rheumatoid arthritis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Nonsteroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a population-based cohort study.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Clinical trial of indomethacin in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effects of ovariectomy and estradiol benzoate on high affinity choline uptake, ACh synthesis, and release from rat cerebral cortical synaptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estrogen as a growth factor to central nervous cells. Estrogen treatment promotes development of acetylcholinesterase-positive basal forebrain neurons transplanted in the anterior eye chamber

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Characterization of beta-amyloid peptide from human cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

The C-terminus of the beta protein is critical in amyloidogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Genetic neurodegenerative diseases: the human illness and transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Neuroprotective effects of estrogens: potential mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Alzheimer's disease risk factors as related to cerebral blood flow: additional evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Non-genomic effects of estrogen and the vessel wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Atrial fibrillation and dementia in a population-based study. The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Association of diabetes mellitus and dementia: the Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estrogen deficiency and risk of Alzheimer's disease in women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Smoking and oestrogen-replacement therapy as protective factors for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Control-informant agreement on exposure history in case-control studies of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Activation of macrophages by Alzheimer beta amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Association between nutritional status and cognitive functioning in a healthy elderly population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Intake of flavonoids and risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Histamine increases the bursting activity of pyramidal cells in the CA3 region of mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Effect of histamine H2 and H3 receptor modulation in the septum on post-training memory processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Histamine H2 blocking drugs and the risk for Alzheimer's disease: the Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Biochemical aspect of HMG CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Link between heart disease, cholesterol, and Alzheimer's disease: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Clinical studies of cerebral blood flow in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Brain microvascular changes in Alzheimer's disease and other dementias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Statins and the risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Total serum homocysteine in senile dementia of Alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Beta-amyloid therapies in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Experimental approaches and drugs in development for the treatment of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

The evaluation of multiple surrogate endpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Pharmacogenetics and the practice of medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?: The Rotterdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

NSAIDs and incident Alzheimer’s disease. the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.3.4.365

21 January 2018

Identifiers

DOI

10.1517/14656566.3.4.365

1 reference

3 August 2017

1 reference