(Q34592330)

3 August 2017

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title

Using nuclear targeting signals to enhance non-viral gene transfer (English)

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3 August 2017

Chee-Kai Chan

1

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3 August 2017

David A Jans

series ordinal

2

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3 August 2017

publication date

1 April 2002

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Immunology & Cell Biology

3 August 2017

published in

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3 August 2017

volume

80

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3 August 2017

issue

2

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3 August 2017

page(s)

119-130

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Gene therapy -- promises, problems and prospects

3 August 2017

cites work

1 reference

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21 January 2018

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Synthetic DNA delivery systems

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Viral vectors for gene therapy

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Virus treatment questioned after gene therapy death

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Recent progress in gene delivery using non-viral transfer complexes

21 January 2018

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Non-viral vectors in cancer gene therapy: principles and progress

21 January 2018

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Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

21 January 2018

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Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA.

21 January 2018

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Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer.

21 January 2018

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Nucleocytoplasmic transport: signals, mechanisms and regulation

21 January 2018

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Gatekeepers of the nucleus

21 January 2018

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High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores

21 January 2018

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Regulation of protein transport to the nucleus: central role of phosphorylation

21 January 2018

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The nuclear pore complex as a transport machine.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97

21 January 2018

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Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha

21 January 2018

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The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Importin beta mediates nuclear translocation of Smad 3

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The role of Ran in nuclear function.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Transport between the cell nucleus and the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear import of Ran is mediated by the transport factor NTF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Sequence requirements for nuclear location of simian virus 40 large-T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Transferrin-polycation conjugates as carriers for DNA uptake into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Receptor-mediated gene transfer into macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

High-efficiency transfer of cystic fibrosis transmembrane conductance regulator cDNA into cystic fibrosis airway cells in culture using lactosylated polylysine as a vector.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Targeting DNA to cells with basic fibroblast growth factor (FGF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Electron microscopy and biochemical properties of polyamine-compacted DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nucleus-specific and temporally restricted localization of proteins in Tetrahymena macronuclei and micronuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

An amino-terminal fragment of GAL4 binds DNA as a dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Gene transfer using a novel fusion protein, GAL4/invasin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear Import of Creb and AP-1 Transcription Factors Requires Importin-β1 and Ran but Is Independent of Importin-α

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Synergy of importin alpha recognition and DNA binding by the yeast transcriptional activator GAL4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

A novel nuclear import pathway for the transcription factor TFIIS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Nuclear targeting signal recognition: a key control point in nuclear transport?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Transport routes through the nuclear pore complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Transport of proteins and RNAs in and out of the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

A novel receptor-mediated nuclear protein import pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

The regulation of protein transport to the nucleus by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

A consensus cAMP-dependent protein kinase (PK-A) site in place of the CcN motif casein kinase II site simian virus 40 large T-antigen confers PK-A-mediated regulation of nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.2002.01061.X

10.1046/J.1440-1711.2002.01061.X

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference