(Q34597949)

3 August 2017

title

The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets (English)

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systemic lupus erythematosus

3 August 2017

1 reference

1 reference

Wen-Hai Shao

1

1 reference

3 August 2017

Philip L Cohen

series ordinal

2

1 reference

3 August 2017

publication date

29 March 2014

1 reference

Expert Review of Clinical Immunology

3 August 2017

published in

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3 August 2017

volume

10

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3 August 2017

issue

5

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3 August 2017

page(s)

573-582

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Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy.

3 August 2017

cites work

1 reference

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Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Ibrutinib and novel BTK inhibitors in clinical development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Ibrutinib (PCI-32765), the first BTK (Bruton's tyrosine kinase) inhibitor in clinical trials

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Regulation of the SRC family kinases by Csk.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Platelet-derived growth factors and their receptors: structural and functional perspectives

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Genetic associations of LYN with systemic lupus erythematosus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Immunobiology of the TAM receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Is there a future for small molecule drugs in the treatment of rheumatic diseases?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

TAM receptors are pleiotropic inhibitors of the innate immune response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

PTPN22: setting thresholds for autoimmunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Tec kinases: a family with multiple roles in immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Syk tyrosine kinase required for mouse viability and B-cell development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

The ltk gene encodes a novel receptor-type protein tyrosine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Renal platelet-derived growth factor gene expression in NZB/W F1 mice with lupus and ddY mice with IgA nephropathy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4249585

Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation

7 July 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Lack of association of TYK2 gene polymorphisms in Chinese patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Dysregulation of p56lck kinase in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Imatinib ameliorates renal disease and survival in murine lupus autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2014.893827

Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families

21 January 2018

1 reference

12 December 2020

Lack of interaction between systemic lupus erythematosus-associated polymorphisms in TYK2 and IRF5

1 reference

12 December 2020

B-cell kinase lyn deficiency in patients with systemic lupus erythematosus

1 reference

12 December 2020

Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients

1 reference

12 December 2020

Reversal of hyporesponsiveness in lpr CD4-CD8- T cells is achieved by induction of cell cycling and normalization of CD2 and p59fyn expression

1 reference

12 December 2020

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1 reference

12 December 2020

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1 reference

12 December 2020

The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion

1 reference

12 December 2020

Expression of platelet-derived growth factor in lupus nephritis in MRL/MpJ-1pr/1pr mice

1 reference

12 December 2020

[Impact of platelet derived growth factor in the glomeruli of active lupus nephritis]

1 reference

12 December 2020

Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus

1 reference

12 December 2020

Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus

1 reference

12 December 2020

10.1586/1744666X.2014.893827

Identifiers

DOI

1 reference

3 August 2017

1 reference

3 August 2017

1 reference