(Q34607187)

3 August 2017

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis (English)

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3 August 2017

Sofi G Julien

1

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3 August 2017

Nadia Dubé

2

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3 August 2017

Michelle Read

3

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3 August 2017

Janice Penney

4

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3 August 2017

Marilene Paquet

5

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3 August 2017

Yongxin Han

6

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3 August 2017

Brian P Kennedy

7

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3 August 2017

William J Muller

8

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3 August 2017

Michel L Tremblay

9

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3 August 2017

language of work or name

English

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publication date

28 January 2007

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3 August 2017

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3 August 2017

39

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3 August 2017

3

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3 August 2017

338-346

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https://scigraph.springernature.com/pub.10.1038/ng1963

3 August 2017

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cites work

Focus on breast cancer

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 January 2018

1 reference

Transgenic mouse models of human breast cancer

21 January 2018

1 reference

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

21 January 2018

1 reference

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors

21 January 2018

1 reference

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

21 January 2018

1 reference

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

21 January 2018

1 reference

Essential function for ErbB3 in breast cancer proliferation

21 January 2018

1 reference

A novel splice variant of HER2 with increased transformation activity

21 January 2018

1 reference

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

21 January 2018

1 reference

Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP.

21 January 2018

1 reference

Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development

21 January 2018

1 reference

The role of protein tyrosine phosphatase 1B in Ras signaling

21 January 2018

1 reference

Src family kinases in tumor progression and metastasis

21 January 2018

1 reference

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

21 January 2018

1 reference

Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand

21 January 2018

1 reference

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis

21 January 2018

1 reference

The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

21 January 2018

1 reference

Activation of AKT kinases in cancer: implications for therapeutic targeting

21 January 2018

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Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

21 January 2018

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

21 January 2018

1 reference

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

21 January 2018

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ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

21 January 2018

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Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

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Perturbations of the AKT signaling pathway in human cancer

21 January 2018

1 reference

Protein tyrosine phosphatases and breast cancer.

21 January 2018

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

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Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

21 January 2018

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The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

21 January 2018

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Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.

21 January 2018

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

21 January 2018

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Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

21 January 2018

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Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

21 January 2018

1 reference

Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment

21 January 2018

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The FUTURE of ErbB-1 and ErbB-2 pathway inhibition in breast cancer: targeting multiple receptors

21 January 2018

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Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

21 January 2018

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7 January 2021

Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas

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7 January 2021

Role of SRC kinases in Neu-induced tumorigenesis: challenging the paradigm using Csk homologous kinase transgenic mice

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7 January 2021

Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding

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7 January 2021

Identifiers

DOI

10.1038/NG1963

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3 August 2017

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