(Q34613841)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Scott A. Wildman

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

8

Kevan M Shokat

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Chao Zhang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Michael S Lopez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Keliang Tang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Jennifer Barks

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Qiuling Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

L David Sibley

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

English

0 references

publication date

26 March 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

25 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

3068-3077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology

25 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Invasion and intracellular survival by protozoan parasites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Discovery and ADMET: Where are we now.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Structures of parasitic CDPK domains point to a common mechanism of activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

How apicomplexan parasites move in and out of cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Calcium-dependent signaling and kinases in apicomplexan parasites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

The role of fluorine in medicinal chemistry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Medicinal chemical properties of successful central nervous system drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

A chemical switch for inhibitor-sensitive alleles of any protein kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Acquisition of inhibitor-sensitive protein kinases through protein design

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

1NM-PP1 treatment of mice infected with Toxoplasma gondii.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625458

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23470217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Secretion of micronemal proteins is associated with toxoplasma invasion of host cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23470217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural basis for selective inhibition of Src family kinases by PP1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23470217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM4001314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23470217%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference