(Q34615287)

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The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients

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Europe PubMed Central

PubMed publication ID

3 August 2017

The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Alessandra Testa

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Alessandra Testa

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Davide Lauro

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Sabrina Prudente

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Sabrina Prudente

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Alessandro Doria

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Alessandro Doria

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Massimo Federici

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Massimo Federici

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Massimiliano Copetti

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Massimiliano Copetti

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Vincenzo Trischitta

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Vincenzo Trischitta

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Salvatore De Cosmo

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Salvatore De Cosmo

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Carmine Zoccali

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Carmine Zoccali

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Simonetta Bacci

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Simonetta Bacci

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3 August 2017

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Stefano Rizza

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Belinda Spoto

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Antonio Pacilli

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Antonio Pacilli

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3 August 2017

Francesca Mallamaci

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Francesca Mallamaci

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3 August 2017

Giovanni Tripepi

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Giovanni Tripepi

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3 August 2017

Davide Mangiacotti

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Davide Mangiacotti

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Filippo Aucella

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Filippo Aucella

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17

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Renato Lauro

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3 August 2017

Ernest V Gervino

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Ernest V Gervino

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3 August 2017

Fabio Pellegrini

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Fabio Pellegrini

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3 August 2017

author name string

Christine Powers

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3 August 2017

Antonio Facciorusso

6

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3 August 2017

Yuan-Yuan Zhang

10

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3 August 2017

Giuseppe Di Stolfo

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Europe PubMed Central

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3 August 2017

Rui Xu

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3 August 2017

Thomas H Hauser

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3 August 2017

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publication date

31 January 2011

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3 August 2017

number of pages

8

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Europe PubMed Central

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3 August 2017

60

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Europe PubMed Central

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3 August 2017

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

1000-1007

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Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 August 2021

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April 2022 Public Data File from Crossref

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Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Genomewide association analysis of coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Cardiovascular actions of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

ENPP1 K121Q polymorphism is not related to type 2 diabetes mellitus, features of metabolic syndrome, and diabetic cardiovascular complications in a Chinese population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

A common allele on chromosome 9 associated with coronary heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

A common variant on chromosome 9p21 affects the risk of myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Diabetes and obesity: the twin epidemics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Role of endothelial dysfunction in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The metabolic syndrome and chronic kidney disease in U.S. adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Genetics of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Comparison of meta-analysis versus analysis of variance of individual patient data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

7 July 2018

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Diabetics on dialysis in Italy: a nationwide epidemiological study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Impact of body mass index on cardiac mortality in patients with known or suspected coronary artery disease undergoing myocardial perfusion single-photon emission computed tomography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

The K121Q polymorphism in the plasma cell membrane glycoprotein 1 gene predisposes to early myocardial infarction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

The effect of age on the association between body-mass index and mortality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

26 October 2018

Overweight and obesity and the burden of disease and disability in elderly men

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046818

9 December 2018

ENPP1 Q121 Variant, Increased Pulse Pressure and Reduced Insulin Signaling, and Nitric Oxide Synthase Activity in Endothelial Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB10-1300

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Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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