(Q34615453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Daniel Christ

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Cecile King

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

6

Jonathan Sprent

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

Helen M McGuire

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Stacey Walters

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Carol M Y Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Kylie E Webster

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Shane Grey

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

language of work or name

English

0 references

publication date

1 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

number of pages

9

1 reference

inferred from page(s)

published in

Diabetes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

60

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

page(s)

867-875

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

23 January 2020

copyright license

start time

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3046847/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

7 July 2018

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IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

7 July 2018

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IL-21 is critical for GVHD in a mouse model

7 July 2018

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A vital role for interleukin-21 in the control of a chronic viral infection

7 July 2018

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IL-21 is required to control chronic viral infection

7 July 2018

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Interleukin-21 is required for the development of type 1 diabetes in NOD mice

7 July 2018

1 reference

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IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

7 July 2018

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IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms

7 July 2018

1 reference

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

7 July 2018

1 reference

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Interleukin 21: a cytokine/cytokine receptor system that has come of age

7 July 2018

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

7 July 2018

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IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells

7 July 2018

1 reference

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T cell immunomodulation--the Holy Grail of therapeutic tolerance

7 July 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

7 July 2018

1 reference

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046847

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

7 July 2018

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Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration

7 July 2018

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IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response

7 July 2018

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The NOD mouse: a model of immune dysregulation

7 July 2018

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IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

7 July 2018

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

7 July 2018

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7 July 2018

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A critical role for IL-21 in regulating immunoglobulin production

7 July 2018

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Reversal of established autoimmune diabetes by restoration of endogenous beta cell function

7 July 2018

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The initiation of autoimmune diabetes

7 July 2018

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7 July 2018

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IL-1 produced and released endogenously within human islets inhibits beta cell function

7 July 2018

1 reference

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7 July 2018

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Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance?

7 July 2018

1 reference

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Beta cell apoptosis in T cell-mediated autoimmune diabetes

7 July 2018

1 reference

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Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells

7 July 2018

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B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

7 July 2018

1 reference

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

7 July 2018

1 reference

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Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

7 July 2018

1 reference

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Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.

7 July 2018

1 reference

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Insulin independence after islet transplantation into type I diabetic patient

7 July 2018

1 reference

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IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

7 July 2018

1 reference

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Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation

26 October 2018

1 reference

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Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.

26 October 2018

1 reference

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Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.

26 October 2018

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Very slow turnover of beta-cells in aged adult mice

26 October 2018

1 reference

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MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046847

Diabetes results from a late change in the autoimmune response of NOD mice

26 October 2018

1 reference

12 December 2020

Cellular and molecular changes accompanying the progression from insulitis to diabetes

1 reference

12 December 2020

Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus

1 reference

12 December 2020

Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure

1 reference

12 December 2020

Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage

1 reference

12 December 2020

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

12 December 2020

Interleukin-21: an interleukin-2 dependent player in rejection processes

1 reference

12 December 2020

Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses

1 reference

12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

12 December 2020

The role of CD8+ and CD4+ cells in islet allograft rejection

1 reference

12 December 2020

Isolation of leukocytes infiltrating the islets of Langerhans of diabetes-prone mice for flow cytometric analysis

1 reference

12 December 2020

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB10-1157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21357471%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

21357471

1 reference