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HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.
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Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
title
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
main subject
apoptotic process
1 reference
based on heuristic
inferred from title
author
Gabriella D'Orazi
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
author name string
Lavinia Nardinocchi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
Rosa Puca
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
publication date
1 January 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
published in
Aging
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
volume
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
page(s)
33-43
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
cites work
Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Awakening guardian angels: drugging the p53 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
HIPK2 modulates p53 activity towards pro-apoptotic transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
HIPK2: a multitalented partner for transcription factors in DNA damage response and development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Hypoxia-inducible factors, stem cells, and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Restoration of p53 function leads to tumour regression in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
P53 and prognosis: new insights and further complexity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Targeting HIF-1 for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
High-efficiency transformation of mammalian cells by plasmid DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
7 July 2018
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047137
retrieved
26 October 2018
High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21248371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/AGING.100254
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
PMC publication ID
3047137
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
PubMed publication ID
21248371
1 reference
stated in
Europe PubMed Central
PMC publication ID
3047137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21248371%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
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