(Q37761824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

review article

1 reference

title

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

author name string

R Puca

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

L Nardinocchi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

31 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

issue

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

4378-4387

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20514025%20AND%20SRC:MED&resulttype=core&format=json

HIPK2: a versatile switchboard regulating the transcription machinery and cell death

4 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Post-translational modification of p53 in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Awakening guardian angels: drugging the p53 pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

The p53 pathway: positive and negative feedback loops

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Mdm2 promotes the rapid degradation of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Structure-function-rescue: the diverse nature of common p53 cancer mutants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Roles of Nox1 and other Nox isoforms in cancer development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Roles of Axin in the Wnt signalling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Role of nuclear bodies in apoptosis signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Regulation of p53 stability by Mdm2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Negative control of p53 by Sir2alpha promotes cell survival under stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Apoptotic threshold is lowered by p53 transactivation of caspase-6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 modulates p53 activity towards pro-apoptotic transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

31 March 2020

Mdm2: p53's lifesaver?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

The genetics of the p53 pathway, apoptosis and cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Live or let die: the cell's response to p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.183