(Q34616822)

3 August 2017

title

Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy (English)

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3 August 2017

main subject

spinal muscular atrophy

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1 reference

Adrian Robert Krainer

15

object named as

Adrian R Krainer

1 reference

3 August 2017

Michelle L Hastings

1

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author name string

Joel Berniac

2

1 reference

3 August 2017

Ying Hsiu Liu

3

1 reference

3 August 2017

Paul Abato

4

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3 August 2017

Francine M Jodelka

5

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3 August 2017

Lea Barthel

6

1 reference

3 August 2017

Sujatha Kumar

7

1 reference

3 August 2017

Caroline Dudley

8

1 reference

3 August 2017

Mark Nelson

9

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3 August 2017

Kelley Larson

10

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3 August 2017

Jason Edmonds

11

1 reference

3 August 2017

Todd Bowser

12

1 reference

3 August 2017

Michael Draper

13

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3 August 2017

Paul Higgins

14

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3 August 2017

language of work or name

English

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publication date

1 November 2009

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Science Translational Medicine

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

5

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3 August 2017

page(s)

5ra12

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describes a project that uses

3 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2818805/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2818805/fullTextXML

inferred from PubMed Central ID database lookup

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7 July 2018

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7 July 2018

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Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice

7 July 2018

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Salbutamol increases SMN mRNA and protein levels in spinal muscular atrophy cells

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia

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7 July 2018

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7 July 2018

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Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number

7 July 2018

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Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism

7 July 2018

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7 July 2018

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INHIBITION OF PROTEIN SYNTHESIS BY CHLORTETRACYCLINE IN THE E. COLI IN VITRO SYSTEM

7 July 2018

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Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

7 July 2018

1 reference

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7 July 2018

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7 July 2018

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hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

The molecular bases of spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Pre-mRNA splicing in the new millennium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Animal models of spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A mouse model for spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A BRCA1 nonsense mutation causes exon skipping

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

The survival motor neuron protein in spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Correlation between severity and SMN protein level in spinal muscular atrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A novel nuclear structure containing the survival of motor neurons protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Identification and characterization of a spinal muscular atrophy-determining gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Phase I trial of aclacinomycin A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions

7 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000208

Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000208

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000208

Correction of disease-associated exon skipping by synthetic exon-specific activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3000208

Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818805

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20161659

12 December 2020

inferred from PubMed ID database lookup

International SMA consortium meeting. (26-28 June 1992, Bonn, Germany)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20161659

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1126/SCITRANSLMED.3000208

1 reference

3 August 2017

1 reference

3 August 2017

1 reference