(Q34619406)

3 August 2017

title

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1. (English)

1 reference

3 August 2017

0 references

4

Emma J Shanks

1 reference

3 August 2017

Han B Ong

2

0 references

David A Robinson

David A Robinson

5

0 references

Ruth Brenk

Ruth Brenk

10

0 references

Paul G. Wyatt

Paul G Wyatt

9

0 references

Ian H. Gilbert

Ian H Gilbert

12

0 references

Alan Fairlamb

Alan H Fairlamb

11

0 references

Daniel Spinks

1

Daniel Spinks

1 reference

3 August 2017

6

Iain T Collie

1 reference

3 August 2017

Chidochangu P Mpamhanga

3

Chidochangu P Mpamhanga

1 reference

3 August 2017

8

Julie A Frearson

1 reference

3 August 2017

Kevin D Read

7

1 reference

3 August 2017

publication date

29 December 2010

1 reference

3 August 2017

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3 August 2017

volume

6

1 reference

3 August 2017

issue

2

1 reference

3 August 2017

page(s)

302-308

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Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

3 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Opportunities and Challenges in Antiparasitic Drug Discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

The Genome of the African Trypanosome Trypanosoma brucei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Chemotherapy of human African trypanosomiasis: current and future prospects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Peroxidase catalysed aerobic degradation of 5,6,7,8-tetrahydrobiopterin at physiological pH.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Methotrexate, a high-affinity pseudosubstrate of dihydrofolate reductase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000450

Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000450

Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047710

Sulfonate salts of substituted benzimidazoles

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21275054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000450

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201000450

1 reference

3 August 2017

1 reference

3 August 2017

1 reference