(Q34620898)

English

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084834%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3) (English)

1 reference

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16 January 2020

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16 January 2020

Jonathan S. Harrison

4

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16 January 2020

Michael Danilenko

5

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16 January 2020

author name string

Xuening Wang

1

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16 January 2020

Victoria Novik

3

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16 January 2020

George P Studzinski

6

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16 January 2020

publication date

15 November 2010

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16 January 2020

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16 January 2020

9

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16 January 2020

4542-4551

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16 January 2020

22

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16 January 2020

describes a project that uses

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11 June 2022

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based on heuristic

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Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells

1 reference

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Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

1 reference

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Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.

1 reference

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Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules

1 reference

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Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants

1 reference

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Identification of hepatoprotective flavonolignans from silymarin

1 reference

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7 July 2018

Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes

1 reference

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7 July 2018

Silibinin--a promising new treatment for cancer

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7 July 2018

Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis

1 reference

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7 July 2018

Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

No evidence supports vitamin E indiscriminate supplementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

MAP kinases in proliferating human colon cancer Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Use of antioxidant supplements during breast cancer treatment: a comprehensive review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Multitargeted therapy of cancer by silymarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

Prostate cancer chemoprevention by silibinin: bench to bedside

1 reference

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hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation

1 reference

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7 July 2018

Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway.

1 reference

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7 July 2018

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

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Enhancement by other compounds of the anti-cancer activity of vitamin D(3) and its analogs.

1 reference

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The restriction point of the cell cycle

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

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Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

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Protein kinase C is not necessary for transforming growth factor beta-induced growth-arrest in leukemia cell lines.

1 reference

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Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

1 reference

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Expression cDNA cloning of a serine kinase transforming gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048050

7 July 2018

The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation

1 reference

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Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

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Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group

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Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

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Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1,25-dihydroxyvitamin D3.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

Alternative ERK5 regulation by phosphorylation during the cell cycle.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

1 reference

https://api.crossref.org/works/10.4161%2FCC.9.22.13790

21 January 2018

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

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1 reference

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1 reference

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1 reference

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Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21084834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21084834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of 1alpha,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21084834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21084834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CC.9.22.13790

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084834%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

Europe PubMed Central

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16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084834%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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