(Q34623667)

3 August 2017

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title

Energy metabolism in the normal and failing heart: potential for therapeutic interventions (English)

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3 August 2017

2

Margaret P Chandler

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3 August 2017

William C Stanley

1

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3 August 2017

1 April 2002

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3 August 2017

Heart Failure Reviews

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3 August 2017

7

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3 August 2017

115-130

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3 August 2017

2

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https://scigraph.springernature.com/pub.10.1023/a:1015320423577

3 August 2017

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cites work

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12 December 2020

Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland

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12 December 2020

Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo

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12 December 2020

Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation

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12 December 2020

Change in expression of heart carnitine palmitoyltransferase I isoforms with electrical stimulation of cultured rat neonatal cardiac myocytes

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12 December 2020

Metabolism of the failing heart

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12 December 2020

Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments

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12 December 2020

Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration

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12 December 2020

Energy metabolism of the heart: from basic concepts to clinical applications

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12 December 2020

Control of maximum rates of glycolysis in rat cardiac muscle

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12 December 2020

Formation of malonyl coenzyme A in rat heart. Identification and purification of an isozyme of A carboxylase from rat heart

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12 December 2020

Fuel selection in animals

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12 December 2020

Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration

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12 December 2020

The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features.

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12 December 2020

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

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12 December 2020

Exercise hemodynamics and myocardial metabolism during long-term beta-adrenergic blockade in severe heart failure

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12 December 2020

The effects of the inhibition of fatty acid oxidation on pyruvate dehydrogenase complex activity in tissues of lean and obese mice

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12 December 2020

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A a

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12 December 2020

Control of glucose utilization in working perfused rat heart

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12 December 2020

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

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12 December 2020

Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic hearts

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12 December 2020

Improved exercise hemodynamic status in dilated cardiomyopathy after beta-adrenergic blockade treatment

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12 December 2020

Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria

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12 December 2020

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

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12 December 2020

Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure

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12 December 2020

Pyruvate: metabolic protector of cardiac performance.

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12 December 2020

Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels.

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12 December 2020

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

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12 December 2020

Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase

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12 December 2020

Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo

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12 December 2020

Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine

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12 December 2020

The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

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12 December 2020

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

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12 December 2020

Pyruvate dehydrogenase influences postischemic heart function

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12 December 2020

Fatty acid oxidation enzyme gene expression is downregulated in the failing heart

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12 December 2020

Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial

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12 December 2020

Myocardial lactate metabolism: evidence of lactate release during net chemical extraction in man

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12 December 2020

Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs

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12 December 2020

Etomoxir improves left ventricular performance of pressure-overloaded rat heart

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12 December 2020

Mechanisms of glycolytic inhibition in ischemic rat hearts

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12 December 2020

Isolation of a malonyl-CoA-sensitive CPT/beta-oxidation enzyme complex from heart mitochondria

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12 December 2020

Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans

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12 December 2020

Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart

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12 December 2020

[Effectiveness of trimetazidine in stable effort angina due to chronic coronary insufficiency. A double-blind versus placebo study]

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12 December 2020

Effect of beta-adrenergic blockade on myocardial function and energetics in congestive heart failure. Improvements in hemodynamic, contractile, and diastolic performance with bucindolol

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12 December 2020

Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart

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12 December 2020

Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria

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12 December 2020

Mechanism of action of oxfenicine on muscle metabolism

1 reference

12 December 2020

Inherited cardiomyopathies

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12 December 2020

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.

1 reference

12 December 2020

Characterization of the malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) of a rat heart mitochondrial particle. Evidence that the catalytic unit is CPTi

1 reference

12 December 2020

Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi.

1 reference

12 December 2020

Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure

1 reference

12 December 2020

Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. US Carvedilol Heart Failure Study Group

1 reference

12 December 2020

Abnormal mitochondrial function in myocardium of dogs with chronic heart failure

1 reference

12 December 2020

Cost-effectiveness analysis in clinical practice: the case of heart failure

1 reference

12 December 2020

Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

1 reference

12 December 2020

Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters

1 reference

12 December 2020

Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat

1 reference

12 December 2020

An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts

1 reference

12 December 2020

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1 reference

12 December 2020

Uncoupling activity of long-chain fatty acids

1 reference

12 December 2020

Pyruvate dehydrogenase activity and malonyl CoA levels in normal and ischemic swine myocardium: effects of dichloroacetate.

1 reference

12 December 2020

Total-body and myocardial substrate oxidation in congestive heart failure.

1 reference

12 December 2020

Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: a randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium

1 reference

12 December 2020

Cardiac fatty acid uptake and transport in health and disease

1 reference

12 December 2020

The link between acute haemodynamic adrenergic beta-blockade and long-term effects in patients with heart failure. A study on diastolic function, heart rate and myocardial metabolism following intravenous metoprolol

1 reference

12 December 2020

Sustained nonoxidative glucose utilization and depletion of glycogen in reperfused canine myocardium.

1 reference

12 December 2020

Long-term therapy with trimetazidine in cardiomyopathic Syrian hamster BIO 14:6

1 reference

12 December 2020

Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy

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12 December 2020

Mechanisms and abnormalities of contractility and relaxation in the failing heart

1 reference

12 December 2020

Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work

1 reference

12 December 2020

Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate

1 reference

12 December 2020

Histologic and biochemical correlates of left ventricular chamber dynamics in man

1 reference

12 December 2020

Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism

1 reference

12 December 2020

Regulation of glucose metabolism in cardiac muscle.

1 reference

12 December 2020

Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy

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12 December 2020

Mitochondrial dysfunction in heart failure: potential for therapeutic interventions?

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12 December 2020

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions

1 reference

12 December 2020

Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.

1 reference

12 December 2020

Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.

1 reference

12 December 2020

Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia

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12 December 2020

Clinical heterogeneity in respiratory chain complex III deficiency in childhood

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12 December 2020

Role of fructose 2,6-bisphosphate in the control of heart glycolysis

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12 December 2020

Influence of metabolic substrate on rat heart function and metabolism at different coronary flows.

1 reference

12 December 2020

CPT-1 inhibition by etomoxir has a chamber-related action on cardiac sarcoplasmic reticulum and isomyosins

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12 December 2020

Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart

1 reference

12 December 2020

Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor Etomoxir

1 reference

12 December 2020

Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction

1 reference

12 December 2020

Ventricular energetics

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12 December 2020

Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study

1 reference

12 December 2020

The causes and functions of mitochondrial proton leak

1 reference

12 December 2020

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

1 reference

12 December 2020

Myocardial lactate release during ischemia in swine. Relation to regional blood flow

1 reference

12 December 2020

Ranolazine: a novel metabolic modulator for the treatment of angina

1 reference

12 December 2020

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1 reference

12 December 2020

Metabolic oxidation of glucose during early myocardial reperfusion

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12 December 2020

Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme

1 reference

12 December 2020

Regulation of fatty acid oxidation in the mammalian heart in health and disease

1 reference

12 December 2020

Oxfenicine diverts rat muscle metabolism from fatty acid to carbohydrate oxidation and protects the ischaemic rat heart

1 reference

12 December 2020

Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation

1 reference

12 December 2020

Inhibition of fatty acid oxidation and decrease of oxygen consumption of working rat heart by 4-bromocrotonic acid

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12 December 2020

Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart

1 reference

12 December 2020

Myocardial lactate metabolism during exercise

1 reference

12 December 2020

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group

1 reference

12 December 2020

Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria

1 reference

12 December 2020

Should manipulation of myocardial substrate utilization patterns be a component of the congestive heart failure therapeutic paradigm?

1 reference

12 December 2020

Mitochondrial abnormalities in myocardium of dogs with chronic heart failure

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12 December 2020

Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia

1 reference

12 December 2020

Dietary medium-chain triglycerides can prevent changes in myosin and SR due to CPT-1 inhibition by etomoxir

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1015320423577

1 reference

PubMed ID

11988636

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

11988636