(Q34624198)

3 August 2017

title

Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodents (English)

1 reference

3 August 2017

0 references

1 reference

Yardana Kaufman

1

1 reference

3 August 2017

Li Ma

series ordinal

2

1 reference

3 August 2017

Ilyas Washington

series ordinal

3

1 reference

3 August 2017

language of work or name

English

0 references

publication date

12 November 2010

1 reference

3 August 2017

number of pages

8

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

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3 August 2017

volume

286

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3 August 2017

issue

10

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3 August 2017

page(s)

7958-7965

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Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation

3 August 2017

cites work

1 reference

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Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy

7 July 2018

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Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

7 July 2018

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The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

7 July 2018

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Superoxidation of retinoic acid

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation

7 July 2018

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Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration

7 July 2018

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Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

7 July 2018

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Prevalence of age-related macular degeneration in the United States

7 July 2018

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The stability of rhodopsin and opsin; effects of pH and aging

7 July 2018

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Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

7 July 2018

1 reference

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The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

7 July 2018

1 reference

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Molecular mechanisms of retinoid action.

7 July 2018

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Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

7 July 2018

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Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

High-performance liquid chromatography and laser desorption/ionization mass spectrometry of retinyl esters

7 July 2018

1 reference

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7 July 2018

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Observation of A2E oxidation products in human retinal lipofuscin

7 July 2018

1 reference

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Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

The phototoxicity of aged human retinal melanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Mechanism of the inhibition of lysosomal functions in the retinal pigment epithelium by lipofuscin retinoid component A2-E

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Detergent-like effects of the lipofuscin retinoid component A2-E in retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

The retinoid cycle and retina disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Synthesis and biological activity of novel retinamide and retinoate derivatives

21 January 2018

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Dietary intake of selected vitamins for the United States population: 1999-2000.

21 January 2018

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Quantitative assessment of total body stores of vitamin A in adults with the use of a 3-d deuterated-retinol-dilution procedure.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048682

Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2)

26 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium Bisretinoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

Retinal age pigments generated by self-assembling lysosomotropic detergents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.178640

21 January 2018

1 reference

12 December 2020

Superoxidation of bisretinoids

1 reference

12 December 2020

1 reference

12 December 2020

Study of the Electrocyclization of (Z)-Hexa-1,3,5-triene and Its Heterosubstituted Analogues Based on Ab Initio and DFT Calculations

1 reference

12 December 2020

1 reference

12 December 2020

Proline promoted synthesis of ring-fused homodimers: self-condensation of alpha,beta-unsaturated aldehydes

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12 December 2020

Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes

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12 December 2020

Clinical development plan: vitamin A

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12 December 2020

Vitamin A in human eyes: amount, distribution, and composition

1 reference

12 December 2020

Liver stores of vitamin A in a normal population dying suddenly or rapidly from unnatural causes in New York City

1 reference

12 December 2020

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.178640

1 reference

3 August 2017

1 reference

3 August 2017

1 reference