(Q34624546)

3 August 2017

title

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice (English)

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3 August 2017

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13

Makoto Kuro-o

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3 August 2017

4

Johanne V Pastor

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3 August 2017

Shigehiro Doi

1

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3 August 2017

Yonglong Zou

2

1 reference

3 August 2017

Osamu Togao

3

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3 August 2017

George B John

5

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3 August 2017

Lei Wang

6

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3 August 2017

Kazuhiro Shiizaki

7

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3 August 2017

Russell Gotschall

8

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3 August 2017

Susan Schiavi

9

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3 August 2017

Noriaki Yorioka

10

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3 August 2017

Masaya Takahashi

11

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3 August 2017

David A Boothman

12

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3 August 2017

language of work or name

English

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publication date

5 January 2011

1 reference

Journal of Biological Chemistry

3 August 2017

published in

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3 August 2017

volume

286

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3 August 2017

issue

10

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3 August 2017

page(s)

8655-8665

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describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3048747/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

7 July 2018

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Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

7 July 2018

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Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction

7 July 2018

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Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

7 July 2018

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Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

7 July 2018

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7 July 2018

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Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

7 July 2018

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7 July 2018

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Klotho is a substrate for alpha-, beta- and gamma-secretase

7 July 2018

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7 July 2018

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7 July 2018

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Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho

7 July 2018

1 reference

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IGF-1 receptor inhibitors in clinical trials--early lessons

7 July 2018

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Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

7 July 2018

1 reference

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Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

7 July 2018

1 reference

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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

7 July 2018

1 reference

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Prevalence of chronic kidney disease in the United States

7 July 2018

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Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations

7 July 2018

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Augmented Wnt signaling in a mammalian model of accelerated aging

7 July 2018

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TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease

7 July 2018

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

7 July 2018

1 reference

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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

7 July 2018

1 reference

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Klotho converts canonical FGF receptor into a specific receptor for FGF23

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Regulation of fibroblast growth factor-23 signaling by klotho

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Specificity and versatility in tgf-beta signaling through Smads

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Suppression of aging in mice by the hormone Klotho

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Development of TGF-beta signalling inhibitors for cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Obstructive nephropathy and renal fibrosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Evidence that fibroblasts derive from epithelium during tissue fibrosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Association of human aging with a functional variant of klotho

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048747

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Klotho reduces apoptosis in experimental ischaemic acute renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Severely reduced production of klotho in human chronic renal failure kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.174037

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys

21 January 2018

1 reference

12 December 2020

Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging

1 reference

12 December 2020

Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction

1 reference

12 December 2020

Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: preliminary experience

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.174037

1 reference

release_2klxvggtxjcjzdwhuhow75hx5y

3 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2klxvggtxjcjzdwhuhow75hx5y

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3048747

1 reference

3 August 2017

1 reference