(Q34626852)

3 August 2017

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title

Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns (English)

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3 August 2017

2

Shimon Sakaguchi

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3 August 2017

Makoto Miyara

1

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3 August 2017

publication date

8 February 2011

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Immunology & Cell Biology

3 August 2017

published in

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3 August 2017

volume

89

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3 August 2017

issue

3

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3 August 2017

page(s)

346-351

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Regulatory T cells and immune tolerance

3 August 2017

cites work

1 reference

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Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy

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FOXP3+ regulatory T cells in the human immune system

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

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Autoreactive T cells in healthy individuals

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CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

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CTLA-4 control over Foxp3+ regulatory T cell function

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

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Human regulatory T cells and autoimmunity

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Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

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21 January 2018

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Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

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Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

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CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies

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The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation

21 January 2018

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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

21 January 2018

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

21 January 2018

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

21 January 2018

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

21 January 2018

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A peripheral circulating compartment of natural naive CD4 Tregs

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Persistence of naive CD45RA+ regulatory T cells in adult life.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Natural regulatory T cells: mechanisms of suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.137

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Expansion of human regulatory T-cells from patients with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

Regulatory T cells in tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

CD4+CD25high regulatory cells in human peripheral blood

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

MHC class II expression identifies functionally distinct human regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

Emerging challenges in regulatory T cell function and biology

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https://api.crossref.org/works/10.1038%2FICB.2010.137

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.137

1 reference

3 August 2017

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