(Q34626969)

3 August 2017

Systems-level antimicrobial drug and drug synergy discovery (English)

1 reference

3 August 2017

Terry Roemer

1

1 reference

PubMed ID

23508188

3 August 2017

Charles Boone

series ordinal

2

1 reference

3 August 2017

1 April 2013

1 reference

3 August 2017

Nature Chemical Biology

1 reference

3 August 2017

9

1 reference

3 August 2017

222-231

1 reference

3 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio.1205

3 August 2017

0 references

cites work

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Why is big Pharma getting out of antibacterial drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Antibiotics for emerging pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Discovery research: the scientific challenge of finding new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

How were new medicines discovered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Systematic identification of essential genes by in vitro mariner mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Comprehensive transposon mutant library of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Essential Bacillus subtilis genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Exploration of essential gene functions via titratable promoter alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Tetracycline-inducible gene expression and gene deletion in Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Essential gene identification and drug target prioritization in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

The bacterial cell envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Confronting the challenges of natural product-based antifungal discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Compound prioritization methods increase rates of chemical probe discovery in model organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

21 January 2018

New uses for old drugs

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Global phenotypic screening for antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genomewide screening for novel genetic variations associated with ciprofloxacin resistance in Bacillus anthracis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Yeast chemical genomics and drug discovery: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Quantitative phenotyping via deep barcode sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Chemical genomic approaches to study model microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

An integrated platform of genomic assays reveals small-molecule bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Defining genetic interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Systematic mapping of genetic interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Systematic genetic analysis with ordered arrays of yeast deletion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Global mapping of the yeast genetic interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

The genetic landscape of a cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Caspofungin: the first in a new class of antifungal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Chitin synthase III: synthetic lethal mutants and "stress related" chitin synthesis that bypasses the CSD3/CHS6 localization pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genetic architecture of intrinsic antibiotic susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Phenotypic landscape of a bacterial cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

The neglected intrinsic resistome of bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. II. Biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Systematic discovery of multicomponent therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Reversal of resistance in microorganisms by help of non-antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Antibiotic adjuvants: multicomponent anti-infective strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Regulatory circuitry governing fungal development, drug resistance, and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Systematic exploration of synergistic drug pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Parsimonious discovery of synergistic drug combinations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Three decades of beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

An insight into the antifungal pipeline: selected new molecules and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

The antibiotic resistome: the nexus of chemical and genetic diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

21 January 2018

The antibiotic resistome

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Biochemical and genetic analysis of the yeast proteome with a movable ORF collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

In vitro and in vivo effects of 14alpha-demethylase (ERG11) depletion in Candida glabrata

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Essentiality of FASII pathway for Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Resistance of human fungal pathogens to antifungal drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Synergistic drug combinations tend to improve therapeutically relevant selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1205

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds

21 January 2018

1 reference

12 December 2020

Chitin synthase inhibitors as antifungal agents.

1 reference

12 December 2020

Synergy, antagonism, and what the chequerboard puts between them

1 reference

12 December 2020

Whither antibacterial drug discovery?

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1205

1 reference

3 August 2017

1 reference

PubMed ID

23508188