(Q34627089)

3 August 2017

title

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle (English)

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3 August 2017

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Jeffery D Molkentin

7

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author name string

Sanjeewa A Goonasekera

1

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3 August 2017

Chi K Lam

2

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3 August 2017

Douglas P Millay

3

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3 August 2017

Michelle A Sargent

4

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3 August 2017

Roger J Hajjar

5

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3 August 2017

Evangelia G Kranias

6

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3 August 2017

language of work or name

English

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publication date

1 March 2011

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Journal of Clinical Investigation

3 August 2017

published in

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3 August 2017

volume

121

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3 August 2017

issue

3

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3 August 2017

page(s)

1044-1052

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Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage

3 August 2017

cites work

1 reference

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Calcium and the damage pathways in muscular dystrophy

7 July 2018

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Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

7 July 2018

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Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

7 July 2018

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Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

7 July 2018

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Emerging strategies for cell and gene therapy of the muscular dystrophies

7 July 2018

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Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

7 July 2018

1 reference

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Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Dystrophic skeletal muscle fibers display alterations at the level of calcium microdomains

7 July 2018

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

7 July 2018

1 reference

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Biology of the striated muscle dystrophin-glycoprotein complex

7 July 2018

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Calcium and cardiomyopathies.

7 July 2018

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Pathophysiology of duchenne muscular dystrophy: current hypotheses

7 July 2018

1 reference

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Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species.

7 July 2018

1 reference

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The role of Ca2+ in muscle cell damage

7 July 2018

1 reference

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Sarcoplasmic reticulum: the dynamic calcium governor of muscle

7 July 2018

1 reference

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Gene expression profiling in dysferlinopathies using a dedicated muscle microarray.

7 July 2018

1 reference

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Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models.

7 July 2018

1 reference

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Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Increased calcium influx in dystrophic muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Sarcoplasmic-endoplasmic-reticulum Ca2+-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficient mdx mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Comparison of the myoplasmic calcium transient elicited by an action potential in intact fibres of mdx and normal mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Effect of cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca-ATPase, on skeletal muscles from normal and mdx mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

The action potential-evoked sarcoplasmic reticulum calcium release is impaired in mdx mouse muscle fibres

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Sarcoplasmic reticulum function in slow- and fast-twitch skeletal muscles from mdx mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Calpains are activated in necrotic fibers from mdx dystrophic mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Common pathological mechanisms in mouse models for muscular dystrophies

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049367

Long-term study of Ca(2+) homeostasis and of survival in collagenase-isolated muscle fibres from normal and mdx mice

9 December 2018

1 reference

12 December 2020

Critical evaluation of cytosolic calcium determination in resting muscle fibres from normal and dystrophic (mdx) mice

1 reference

12 December 2020

The sarcoplasmic reticulum calcium pump is functionally altered in dystrophic muscle

1 reference

12 December 2020

Ectopic Expression of Phospholamban in Fast-Twitch Skeletal Muscle Alters Sarcoplasmic Reticulum Ca2+Transport and Muscle Relaxation

1 reference

12 December 2020

Increased calcium entry into dystrophin-deficient muscle fibres of MDX and ADR-MDX mice is reduced by ion channel blockers

1 reference

12 December 2020

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

12 December 2020

Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1

1 reference

12 December 2020

Gene table of monogenic neuromuscular disorders (nuclear genome only) Vol 19. No 1 January 2009

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI43844

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3 August 2017

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3 August 2017

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