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The histamine H3 receptor: from discovery to clinical trials with pitolisant
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
The histamine H3 receptor: from discovery to clinical trials with pitolisant
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
author
Jean-Charles Schwartz
series ordinal
1
object named as
Jean-Charles Schwartz
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language of work or name
English
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publication date
1 June 2011
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stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
published in
British Journal of Pharmacology
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stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
volume
163
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stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
issue
4
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stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
page(s)
713-721
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stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
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Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications
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Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls.
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7 July 2018
Histamine H3 receptor antagonists go to clinics
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PubMed Central
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7 July 2018
Refined docking as a valuable tool for lead optimization: application to histamine H3 receptor antagonists.
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Histamine H3 antagonists as wake-promoting and pro-cognitive agents
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Histamine in the nervous system
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An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients
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Histamine and schizophrenia
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PubMed Central
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Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.
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Narcolepsy with cataplexy
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PubMed Central
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7 July 2018
Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons
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Histamine H3 receptor antagonists: from target identification to drug leads
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BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology
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Excessive daytime sleepiness in parkinsonism
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7 July 2018
The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders
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PubMed Central
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7 July 2018
Perspectives on cognitive domains, H3 receptor ligands and neurological disease
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Application of genomics to drug design: the example of the histamine H3 receptor.
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Arousal effect of orexin A depends on activation of the histaminergic system
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7 July 2018
Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease
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PubMed Central
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7 July 2018
High constitutive activity of native H3 receptors regulates histamine neurons in brain.
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PubMed Central
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7 July 2018
Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain
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PubMed Central
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7 July 2018
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
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7 July 2018
Cloning and functional expression of the human histamine H3 receptor
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PubMed Central
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7 July 2018
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist
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7 July 2018
Modulation of neurotransmitter release via histamine H3 heteroreceptors
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PubMed Central
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7 July 2018
Histamine-containing neurons in the rat hypothalamus
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PubMed Central
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7 July 2018
Evidence for the presence of a histaminergic neuron system in the rat brain: an immunohistochemical analysis.
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7 July 2018
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
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PubMed Central
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7 July 2018
Brain histidine decarboxylase activity in Parkinson's disease
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PubMed Central
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7 July 2018
Properties and regional distribution of histidine decarboxylase in rat brain
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PubMed Central
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7 July 2018
Catabolism of 3H-histamine in the rat brain after intracisternal administration
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PubMed Central
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7 July 2018
Definition and antagonism of histamine H 2 -receptors
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PubMed Central
reference URL
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7 July 2018
Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Highly potent and selective ligands for histamine H3-receptors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Alternative splicing directs the expression of two D2 dopamine receptor isoforms.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Histaminergic transmission in the mammalian brain
1 reference
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PubMed Central
reference URL
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7 July 2018
Histamine H3 receptor binding sites in rat brain membranes: modulations by guanine nucleotides and divalent cations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Decrease in histamine content and decarboxylase activities in an isolated area of the cerebral cortex of the cat
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PubMed Central
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retrieved
7 July 2018
Histamine as a transmitter in brain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Histamine H2-receptors on single central neurones
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
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7 July 2018
Histaminergic Mechanisms in Brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
retrieved
7 July 2018
Synthesis and release of histamine studied on slices from rat hypothalamus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111674
retrieved
7 July 2018
Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21615387
retrieved
12 December 2020
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Identifiers
DOI
10.1111/J.1476-5381.2011.01286.X
1 reference
stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
PMCID
3111674
1 reference
stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
PubMed ID
21615387
1 reference
stated in
Europe PubMed Central
PubMed ID
21615387
retrieved
3 August 2017
ResearchGate publication ID
51167948
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