(Q34632410)

3 August 2017

title

A yeast chemical genetic screen identifies inhibitors of human telomerase (English)

1 reference

3 August 2017

Lai Hong Wong

1

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Michaela Spitzer

object named as

Michaela Spitzer

3

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Asier Unciti-Broceta

object named as

Asier Unciti-Broceta

2

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author name string

Rachel White

4

1 reference

3 August 2017

Mike Tyers

5

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3 August 2017

Lea Harrington

6

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3 August 2017

publication date

1 March 2013

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3 August 2017

published in

Chemistry and Biology

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3 August 2017

volume

20

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3 August 2017

issue

3

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3 August 2017

page(s)

333-340

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Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis

3 August 2017

cites work

1 reference

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Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen

7 July 2018

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Role of non-nucleoside reverse transcriptase inhibitors in treating HIV-infected children

7 July 2018

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Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation

7 July 2018

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Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms

7 July 2018

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Imetelstat (GRN163L)--telomerase-based cancer therapy

7 July 2018

1 reference

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The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization

7 July 2018

1 reference

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Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors

7 July 2018

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Telomerase and cancer therapeutics

7 July 2018

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Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

7 July 2018

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A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

7 July 2018

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Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment

7 July 2018

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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.

7 July 2018

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Functional links between telomeres and proteins of the DNA-damage response

7 July 2018

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A human telomerase-associated nuclease

7 July 2018

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Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions

7 July 2018

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Humanized telomeres and an attempt to express a functional human telomerase in yeast

7 July 2018

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Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

7 July 2018

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C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity

7 July 2018

1 reference

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

7 July 2018

1 reference

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

7 July 2018

1 reference

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

7 July 2018

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Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast

7 July 2018

1 reference

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Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

7 July 2018

1 reference

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A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

7 July 2018

1 reference

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Reconstitution of human telomerase activity in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650558

Human telomerase contains evolutionarily conserved catalytic and structural subunits

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650558

Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650558

The genetic control of direct-repeat recombination in Saccharomyces: the effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene

7 July 2018

1 reference

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Automated screening in environmental arrays allows analysis of quantitative phenotypic profiles in Saccharomyces cerevisiae.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3650558

Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae

26 October 2018

1 reference

12 December 2020

Loss of a yeast telomere: arrest, recovery, and chromosome loss.

1 reference

12 December 2020

Yeast expression vectors using RNA polymerase III promoters

1 reference

12 December 2020

Est1 and Cdc13 as comediators of telomerase access

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2012.12.008

Identifiers

DOI

1 reference

3 August 2017

1 reference

3 August 2017

1 reference