(Q34635445)

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A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

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Europe PubMed Central

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3 August 2017

A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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13

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Tetsuya Suhara

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Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Sriram Venneti

1

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Europe PubMed Central

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3 August 2017

Brian J Lopresti

2

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3 August 2017

Guoji Wang

3

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3 August 2017

Susan L Slagel

4

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3 August 2017

N Scott Mason

5

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Europe PubMed Central

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3 August 2017

Chester A Mathis

6

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Europe PubMed Central

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3 August 2017

Michelle L Fischer

7

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3 August 2017

Niccole J Larsen

8

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3 August 2017

Amanda D Mortimer

9

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Europe PubMed Central

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3 August 2017

Teresa G Hastings

10

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3 August 2017

Amanda D Smith

11

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3 August 2017

Michael J Zigmond

12

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3 August 2017

Makoto Higuchi

14

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3 August 2017

Clayton A Wiley

15

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3 August 2017

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publication date

7 June 2007

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3 August 2017

Journal of Neurochemistry

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3 August 2017

102

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3 August 2017

6

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3 August 2017

2118-2131

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3 August 2017

Visualising microglial activation in vivo

1 reference

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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In-vivo measurement of activated microglia in dementia

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In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion.

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21 January 2018

In vivo imaging of neuroinflammation

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In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy

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Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease.

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Peripheral benzodiazepine receptors and mitochondrial function

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Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

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Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization

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Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

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PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

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[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

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21 January 2018

Microglia as mediators of inflammatory and degenerative diseases

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Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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21 January 2018

Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration

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Behavior, neurochemistry and histology after intranigral lipopolysaccharide injection.

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Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

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21 January 2018

Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain

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21 January 2018

Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis

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21 January 2018

A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography

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21 January 2018

Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion.

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21 January 2018

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.

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21 January 2018

Microglial activation and dopamine terminal loss in early Parkinson's disease

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21 January 2018

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.

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21 January 2018

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

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Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain.

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21 January 2018

Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study.

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Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.

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Monitoring by PET of macrophage accumulation in brain after ischaemic stroke.

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Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease

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Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats

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Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time.

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The role of microglia and macrophages in the pathophysiology of the CNS.

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Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

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Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.

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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS

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The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging

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Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.

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Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.

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[(11)C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain

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10.1111/J.1471-4159.2007.04690.X

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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