(Q34635500)

3 August 2017

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title

Peroxisome proliferator activated receptors and obesity (English)

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3 August 2017

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Sander Kersten

1

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language of work or name

English

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publication date

1 April 2002

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European Journal of Pharmacology

3 August 2017

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3 August 2017

440

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3 August 2017

2-3

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3 August 2017

223-234

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Adipose tissue as an endocrine organ

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Efficacy of troglitazone on body fat distribution in type 2 diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Nuclear hormone receptors and gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Conjugated linoleic acid reduces body fat mass in overweight and obese humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Troglitazone action is independent of adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptors in inflammation control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptors: nuclear control of metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Association between polymorphisms in candidate genes and morbid obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Leptin and the regulation of body weight in mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Expression of peroxisome proliferator-activated receptors in lean and obese Zucker rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Relationships of PPARγ and PPARγ2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A comparison in a clinical setting of the efficacy and side effects of three thiazolidinediones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Leptin, peroxisome proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptor gamma 2 Pro12Ala gene variant is strongly associated with larger body mass in the Taiwanese.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

PPAR delta functions as a prostacyclin receptor in blastocyst implantation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Evidence for gene-nutrient interaction at the PPARgamma locus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Differential block by troglitazone and rosiglitazone of glibenclamide-sensitive K(+) current in rat aorta myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma 2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Subcutaneous or visceral adipose tissue expression of the PPARgamma gene is not altered in the fatty (fa/fa) Zucker rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

The hormone resistin links obesity to diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Lipotoxic diseases of nonadipose tissues in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Pro12Ala mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) and severe obesity: a case-control study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor- Gene Are Associated with Severe Overweight among Obese Women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Novel form of lipolysis induced by leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Conjugated linoleic acid: implications for human health

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

Troglitazone induces GLUT4 translocation in L6 myotubes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901431-0

10.1016/S0014-2999(02)01431-0

7 January 2021

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

12007538