(Q34637610)

3 August 2017

title

CGRP receptor antagonists: an expanding drug class for acute migraine? (English)

1 reference

3 August 2017

1 reference

4

Paolo Martelletti

1 reference

3 August 2017

Andrea Negro

1

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3 August 2017

Luana Lionetto

series ordinal

2

1 reference

3 August 2017

Maurizio Simmaco

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

19 April 2012

1 reference

Expert Opinion on Investigational Drugs

3 August 2017

published in

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3 August 2017

volume

21

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3 August 2017

issue

6

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3 August 2017

page(s)

807-818

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Population variation in migraine prevalence: a meta-analysis.

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The neuronal versus vascular hypothesis of migraine and cortical spreading depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Neurogenic Model of Migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide: functional role in cerebrovascular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide (CGRP) and the pathophysiology of headache: therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: mediation by calcitonin gene‐related peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Neurogenic inflammation: a study of rat trigeminal ganglion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

An examination of neurogenic mechanisms involved in mustard oil-induced inflammation in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene-related peptide in human temporal arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Distribution and effects of neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide in human middle meningeal arteries: Comparison with cerebral and temporal arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Evidence for CGRP re-uptake in rat dura mater encephali

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide and its role in migraine pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Neuropeptide changes in a case of chronic paroxysmal hemicrania--evidence for trigemino-parasympathetic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Plasma levels of calcitonin gene-related peptide in chronic tension-type headache.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin Gene-Related Peptide Does Not Cause Migraine Attacks in Patients With Familial Hemiplegic Migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

No increase of calcitonin gene-related peptide in jugular blood during migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Migraine--current understanding and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Differential distribution of 5HT1D- and 5HT1B-immunoreactivity within the human trigemino-cerebrovascular system: implications for the discovery of new antimigraine drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Neurogenic inflammation in the context of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Migraine headache recurrence: relationship to clinical, pharmacological, and pharmacokinetic properties of triptans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Medication overuse headache

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Chronic migraine plus medication overuse headache: two entities or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Chest symptoms after sumatriptan: a two-year clinical practice review in 735 consecutive migraine patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Consensus statement: cardiovascular safety profile of triptans (5-HT agonists) in the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Post-triptan era for the treatment of acute migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

CGRP and migraine: neurogenic inflammation revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of BIBN4096BS on cardiac output distribution and on CGRP-induced carotid haemodynamic responses in the pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Future drugs for migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized, controlled trial of telcagepant over four migraine attacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Long-Term Tolerability of Telcagepant for Acute Treatment of Migraine in a Randomized Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized, controlled trial of telcagepant for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Possible site of action of CGRP antagonists in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The N-Terminal Extracellular Domain 23−60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor Activity-Modifying Protein 1†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

10.1517/13543784.2012.681044

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference