(Q34641933)

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Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

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Europe PubMed Central

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3 August 2017

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection (English)

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3 August 2017

Simian immunodeficiency virus

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12

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21

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Anthony S Fauci

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Joseph Hiatt

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Nagadenahalli Byrareddy Siddappa

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Siddappa N Byrareddy

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3 August 2017

Aftab A. Ansari

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Aftab A Ansari

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4

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Claudia Cicala

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3 August 2017

Francois Villinger

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Francois Villinger

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3 August 2017

3

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James Arthos

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3 August 2017

Markus Brameier

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Markus Brameier

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Ann E Mayne

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3 August 2017

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Brianne Kallam

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Fatima Nawaz

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3 August 2017

Ellen N Kersh

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Janet M McNicholl

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Debra Hanson

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3 August 2017

Keith A Reimann

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3 August 2017

Kenneth Rogers

13

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3 August 2017

Paul Dunbar

15

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Tara Villinger

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Dawn Little

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Tristram G Parslow

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Philip J Santangelo

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3 August 2017

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publication date

24 November 2014

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3 August 2017

Nature Medicine

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3 August 2017

20

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12

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3 August 2017

1397-1400

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3 August 2017

Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis

1 reference

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Vedolizumab for the treatment of IBD: a selective therapeutic approach targeting pathogenic a4b7 cells.

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Vedolizumab as induction and maintenance therapy for ulcerative colitis

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7 July 2018

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

1 reference

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7 July 2018

Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques

1 reference

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In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome

1 reference

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Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of α4β7 binding

1 reference

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Animal models for microbicide studies

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Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility

1 reference

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7 July 2018

Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques

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Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques

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7 July 2018

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission

1 reference

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7 July 2018

Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques

1 reference

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7 July 2018

Resistance to Simian HIV infection is associated with high plasma interleukin-8, RANTES and Eotaxin in a macaque model of repeated virus challenges

1 reference

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7 July 2018

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4257865

7 July 2018

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

1 reference

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7 July 2018

Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing

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Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.

1 reference

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7 July 2018

Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection.

1 reference

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Assessing vaccine effects in repeated low-dose challenge experiments.

1 reference

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The mucosal barrier and immune activation in HIV pathogenesis

1 reference

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HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

1 reference

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No evidence for consistent virus-specific immunity in simian immunodeficiency virus-exposed, uninfected rhesus monkeys

1 reference

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Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges

1 reference

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Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract

1 reference

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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

1 reference

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Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis

1 reference

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Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes

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Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined

1 reference

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Characterization and allelic polymorphisms of rhesus macaque (Macaca mulatta) IgG Fc receptor genes.

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1 reference

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21 January 2018

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10.1038/NM.3715

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

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Europe PubMed Central

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3 August 2017

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