(Q34646525)

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Biochemical and pharmacological characterization of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline: a biologically relevant neurotoxin?

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

Biochemical and pharmacological characterization of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline: a biologically relevant neurotoxin? (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Gerhard Bringmann

3

object named as

Gerhard Bringmann

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

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Peter Riederer

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Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Paul Foley

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Doris Feineis

4

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Europe PubMed Central

PubMed publication ID

3 August 2017

Ralph Brückner

5

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Europe PubMed Central

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3 August 2017

Manfred Gerlach

6

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Europe PubMed Central

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3 August 2017

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publication date

1 May 2002

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Europe PubMed Central

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3 August 2017

European Journal of Pharmacology

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Europe PubMed Central

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3 August 2017

442

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Europe PubMed Central

PubMed publication ID

3 August 2017

1-2

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Europe PubMed Central

PubMed publication ID

3 August 2017

1-16

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Europe PubMed Central

PubMed publication ID

3 August 2017

Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpyridine

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Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen species.

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Chemical mechanism of the effect of alcohol

1 reference

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Endogenous alkaloids in man, VII: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline--a potential chloral-derived indol alkaloid in man

1 reference

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7 January 2021

Endogenous alkaloids in man. XXVI. Determination of the dopaminergic neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in biological samples using gas chromatography with selected ion monitoring.

1 reference

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7 January 2021

Identification of the dopaminergic neurotoxin 1-trichloromethyl-1,2, 3,4-tetrahydro-beta-carboline in human blood after intake of the hypnotic chloral hydrate

1 reference

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Bromal-derived tetrahydro-beta-carbolines as neurotoxic agents: chemistry, impairment of the dopamine metabolism, and inhibitory effects on mitochondrial respiration

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Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells.

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Metabolism, toxicity, and carcinogenicity of trichloroethylene.

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Health effects of environmental contaminant exposure: an intrafile comparison of the Trichloroethylene Subregistry.

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

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Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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Tissue distribution of trichloroethylene and its metabolites in a forensic case.

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Dopamine uptake inhibitory capacities of beta-carboline and 3,4-dihydro-beta-carboline analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products.

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7 January 2021

Long-term follow-up after single toxic exposure to trichloroethylene.

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Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

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MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

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N-methyl-(R)-salsolinol and its relevance to Parkinson's disease

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1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

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7 January 2021

Trichloroethylene and parkinsonism: a human and experimental observation

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7 January 2021

Trichloroethylene affects learning and decreases myelin in the rat hippocampus.

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7 January 2021

Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway

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7 January 2021

Assessment of the health effects of trichloroethylene

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Kinetics of trichloroethylene elimination from venous blood after acute inhalation poisoning.

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7 January 2021

Functional changes in cocultures of mesencephalon and striatal neurons from embryonic C57/BL6 mice due to low concentrations of 1-methyl-4-phenylpyridinium (MPP+)

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7 January 2021

Potential bioactivated neurotoxicants, N-methylated beta-carbolinium ions, are present in human brain

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7 January 2021

Trichlorethylene and Trigeminal Anaesthesia

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Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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The route and significance of endogenous synthesis of alkaloids in animals

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Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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Ferrous-citrate complex and nigral degeneration: evidence for free-radical formation and lipid peroxidation.

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Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol

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Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms

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Striatal dopaminergic toxicity following intranigral injection in rats of 2-methyl-norharman, a beta-carbolinium analog of N-methyl-4-phenylpyridinium ion (MPP+).

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In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+

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Simultaneous monitoring of dopamine release in rat frontal cortex, nucleus accumbens and striatum: effect of drugs, circadian changes and correlations with motor activity

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Trichloroethylene [correction of Trichloroethene] levels in human blood and exhaled breath from controlled inhalation exposure

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Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP.

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Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanol

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Ethanol induces an increase of harman in the brain and urine of rats

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Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances

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Mitochondrial complex I deficiency in Parkinson's disease

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Interaction of chloral hydrate and ethanol in man. II. Hemodynamics and performance

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Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra

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Indole derivatives as neuroprotectants

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Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain

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Functional studies on monoaminergic transmitter release in parkinsonism

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Intranigral injected iron progressively reduces striatal dopamine metabolism

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Methodological approach to the evaluation of neurotoxicity data and the classification of neurotoxic chemicals

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10.1016/S0014-2999(02)01308-0

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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