(Q34646650)

3 August 2017

title

Immunotoxins for targeted cancer therapy. (English)

1 reference

3 August 2017

Pastan I I

1

1 reference

3 August 2017

Kreitman RJ

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 April 1998

1 reference

Advanced Drug Delivery Reviews

3 August 2017

published in

1 reference

3 August 2017

volume

31

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3 August 2017

issue

1-2

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3 August 2017

page(s)

53-88

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3 August 2017

cites work

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Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1 alpha, 1 beta, and 2 gamma

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Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor

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IL2-ricin fusion toxin is selectively cytotoxic in vitro to IL2 receptor-bearing tumor cells

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Expression and secretion of a recombinant ricin immunotoxin from murine myeloma cells

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Biologically active interleukin 2-ricin A chain fusion proteins may require intracellular proteolytic cleavage to exhibit a cytotoxic effect.

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7 January 2021

Expression and activity of a recombinant chimeric protein composed of pokeweed antiviral protein and of human interleukin-2.

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7 January 2021

Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins.

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Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo

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7 January 2021

Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

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7 January 2021

The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin

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7 January 2021

Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation

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7 January 2021

Active site mutations of Pseudomonas aeruginosa exotoxin A. Analysis of the His440 residue

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7 January 2021

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity

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7 January 2021

Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

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7 January 2021

Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes

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7 January 2021

The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion

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7 January 2021

Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1

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7 January 2021

Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication

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7 January 2021

Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide

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7 January 2021

Refined structure of monomeric diphtheria toxin at 2.3 A resolution

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7 January 2021

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

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7 January 2021

Dynamic transitions of the transmembrane domain of diphtheria toxin: disulfide trapping and fluorescence proximity studies

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7 January 2021

Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin

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7 January 2021

Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery

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7 January 2021

Selective destruction of target cells by diphtheria toxin conjugated to antibody directed against antigens on the cells

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7 January 2021

Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor

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7 January 2021

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

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7 January 2021

Preparation of a hybrid of fragment Fab' of antibody and fragment a of diphtheria toxin and its cytotoxicity

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7 January 2021

Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity

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7 January 2021

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

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7 January 2021

Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.

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7 January 2021

A proper amino terminus of diphtheria toxin is important for cytotoxicity

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7 January 2021

Chronic lymphocytic leukemia: new insights into biology and therapy

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7 January 2021

Peripheral T-cell lymphomas: a clinicopathologic study of 75 cases

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7 January 2021

Efficacy of an anti-CD5-ricin A chain immunoconjugate in an improved human peripheral blood lymphocyte--reconstituted severe combined immunodeficient mouse model

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7 January 2021

In vitro and in vivo properties of an anti-CD5-momordin immunotoxin on normal and neoplastic T lymphocytes

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7 January 2021

Cysteine analogs of recombinant barley ribosome inactivating protein form antibody conjugates with enhanced stability and potency in vitro

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7 January 2021

The IL-2/IL-2 receptor system: a current overview

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7 January 2021

Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients

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7 January 2021

Demonstration of high-affinity interleukin-2 receptors on B-chronic lymphocytic leukemia cells: functional and structural characterization

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7 January 2021

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen

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7 January 2021

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin

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7 January 2021

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein

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7 January 2021

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli

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7 January 2021

Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells.

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7 January 2021

Cardiac allograft survival in mice treated with IL-2-PE40.

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7 January 2021

Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion

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7 January 2021

Interleukin 2-diphtheria toxin fusion protein can abolish cell-mediated immunity in vivo

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7 January 2021

Impact of interleukin-2-receptor-targeted cytotoxins on a unique model of murine interleukin-2-receptor-expressing malignancy

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7 January 2021

Interleukin-2 receptor-specific fusion toxin inhibits barotrauma-induced arterial atherosclerosis

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7 January 2021

Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis

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7 January 2021

Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.

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7 January 2021

In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin

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7 January 2021

Sequential effects of interleukin 2-diphtheria toxin fusion protein on T-cell activation

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7 January 2021

Therapeutic effects of genetically engineered toxin (DAB486IL-2) in patient with chronic lymphocytic leukaemia

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7 January 2021

Phase I trial of the diphtheria toxin/interleukin-2 fusion protein DAB486IL-2: efficacy in mycosis fungoides and other non-Hodgkin's lymphomas

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7 January 2021

Clinical activity of a cytotoxic fusion protein in the treatment of cutaneous T-cell lymphoma

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7 January 2021

Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: complete response in a patient with Hodgkin's disease refractory to chemotherapy

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7 January 2021

Phase I trial of a genetically engineered interleukin-2 fusion toxin (DAB486IL-2) as a 6 hour intravenous infusion in patients with hematologic malignancies.

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7 January 2021

DAB486IL-2 fusion toxin in refractory rheumatoid arthritis

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7 January 2021

Interleukin-2 diphtheria fusion protein (DAB486IL-2) in refractory rheumatoid arthritis. A double-blind, placebo-controlled trial with open-label extension.

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7 January 2021

Expression of interleukin 2 receptors on activated human B cells

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7 January 2021

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

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7 January 2021

Single-chain antigen-binding proteins

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7 January 2021

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

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7 January 2021

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia

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7 January 2021

Targeting Pseudomonas exotoxin to hematologic malignancies

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7 January 2021

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin

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7 January 2021

Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

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7 January 2021

Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin

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7 January 2021

Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model

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7 January 2021

Immunotoxins constructed with anti-CD25 monoclonal antibodies and deglycosylated ricin A-chain have potent anti-tumour effects against human Hodgkin cells in vitro and solid Hodgkin tumours in mice

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7 January 2021

Experimental treatment of human Hodgkin's disease with ricin A-chain immunotoxins

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7 January 2021

Targeting of saporin to CD25-positive normal and neoplastic lymphocytes by an anti-saporin/anti-CD25 bispecific monoclonal antibody: in vitro evaluation

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7 January 2021

CD22 regulates thymus-independent responses and the lifespan of B cells.

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7 January 2021

Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas

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7 January 2021

Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies

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7 January 2021

CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy

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7 January 2021

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation

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7 January 2021

Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia

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7 January 2021

Immunotoxins for the treatment of leukaemia

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7 January 2021

Elimination of B-lineage leukemia and lymphoma cells from bone marrow grafts using anti-B4-blocked-ricin immunotoxin

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7 January 2021

Evaluation of the systemic toxicity and pharmacokinetics of the immunoconjugate anti-B4-blocked ricin in non-human primates. Delivered by multiple bolus injections and by continuous infusion

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7 January 2021

Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms.

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7 January 2021

Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours

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7 January 2021

Therapy of human B-cell lymphoma bearing SCID mice is more effective with anti-CD19- and anti-CD38-saporin immunotoxins used in combination than with either immunotoxin used alone

1 reference

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7 January 2021

Cytotoxicity against human peripheral blood mononuclear cells and T cell lines mediated by anti-T cell immunotoxins in the absence of added potentiator

1 reference

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7 January 2021

Laboratory preparation of a deglycosylated ricin toxin A chain containing immunotoxin directed against a CD7 T lineage differentiation antigen for phase I human clinical studies involving T cell malignancies

1 reference

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7 January 2021

Comparison of the performance of anti-CD7 and anti-CD38 bispecific antibodies and immunotoxins for the delivery of saporin to a human T-cell acute lymphoblastic leukemia cell line

1 reference

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7 January 2021

Therapy of human T-cell acute lymphoblastic leukaemia in severe combined immunodeficient mice with two different anti-CD7-saporin immunotoxins containing hindered or non-hindered disulphide cross-linkers

1 reference

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7 January 2021

Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice

1 reference

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7 January 2021

A new reagent for the induction of T-cell depletion, anti-CD3-CRM9.

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7 January 2021

An anti-CD3 single-chain immunotoxin with a truncated diphtheria toxin avoids inhibition by pre-existing antibodies in human blood

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7 January 2021

Graft-versus-host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings. A pilot study using immunotoxins for T cell depletion of donor bone marrow

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7 January 2021

Cocktails of ricin a‐chain immunotoxins against different antigens on hodgkin and sternberg‐reed cells have superior anti‐tumor effects against H‐RS cells in vitro and solid Hodgkin tumors in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Development of new ricin A‐chain immunotoxins with potent anti‐tumor effects against human hodgkin cells in vitro and disseminated Hodgkin tumors in scid mice using high‐affinity monoclonal antibodies directed against the CD30 antigen

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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Response of refractory Hodgkin's disease to monoclonal anti-CD30 immunotoxin

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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Differential sensitivity of CD30+ neoplastic cells to gelonin delivered by anti-CD30/anti-gelonin bispecific antibodies

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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Anti-CD30 immunotoxins with native and recombinant dianthin 30

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7 January 2021

Immunophenotype of clonogenic cells in myeloid leukaemia

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7 January 2021

Resistance of myeloid leukaemia cell lines to ricin A-chain immunotoxins

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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Characterization of murine and humanized anti-CD33, gelonin immunotoxins reactive against myeloid leukemias

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7 January 2021

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

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7 January 2021

Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells

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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Differential sensitivity of human myeloma cell lines and normal bone marrow colony forming cells to a recombinant diphtheria toxin-interleukin 6 fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Diphtheria toxin receptor-binding domain substitution with interleukin 6: genetic construction and interleukin 6 receptor-specific action of a diphtheria toxin-related interleukin 6 fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxicity of a novel anti-ICAM-1 immunotoxin on human myeloma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Efficacy and toxicity of plasma-cell-reactive monoclonal antibodies B-B2 and B-B4 and their immunotoxins.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Interleukin-4 induces proliferation of adult T-cell leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Selective proteolytic cleavage of recombinant human interleukin 4. Evidence for a critical role of the C-terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Immunochemical mapping of domains in human interleukin 4 recognized by neutralizing monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

The high-resolution, three-dimensional solution structure of human interleukin-4 determined by multidimensional heteronuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A circularly permuted recombinant interleukin 4 toxin with increased activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Activity of a monoclonal antibody-saporin-6 conjugate against B-lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Expression of GM-CSF and a functional GM-CSF receptor in the human colon carcinoma cell line SW403.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxicity of a recombinant diphtheria toxin-granulocyte colony-stimulating factor fusion protein on human leukemic blast cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Immunotoxins containing saporin linked to different CD2 monoclonal antibodies: in vitro evaluation.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Anti-CD6-blocked ricin: an anti-pan T-cell immunotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Blocked ricin-conjugated T cell immunotoxins: effect of anti-CD6-blocked ricin on normal T cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Potent anti-tumor effects of an anti-CD24 ricin A-chain immunotoxin in vitro and in a disseminated human Burkitt's lymphoma model in SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

An anti-CD72 immunotoxin against therapy-refractory B-lineage acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Biodistribution and in vivo antitumor efficacy of the systemically administered anti-human T-leukemia immunotoxins and potentiation of their efficacy by alpha-interferon

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Effects of an anti HLA-DR immunotoxin on leukaemia cells and hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Production and characterization of two immunotoxins specific for M5b ANLL leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

In vivo efficacy of intrathecal transferrin-Pseudomonas exotoxin A immunotoxin against LOX melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Immunotoxins for central nervous system malignancy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Epidermal growth factor-toxin A chain conjugates: EGF-Ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Effects of anti-epidermal growth factor (EGF) receptor antibodies and an anti-EGF receptor recombinant-ricin A chain immunoconjugate on growth of human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Selective killing of squamous carcinoma cells by an immunotoxin that recognizes the EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Human squamous cell lung cancers express increased epidermal growth factor receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Investigation of the expression of epidermal growth factor receptor and blood group A antigen in 110 human gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Epidermal growth factor receptor expression in 72 meningiomas

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Characterization of epidermal growth factor receptor in normal and neoplastic human endometrium

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic effect of a fusion protein from transforming growth factor alpha and Pseudomonas exotoxin on rat and human bladder carcinoma cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

TGF alpha-PE40 inhibits non-small cell lung cancer growth

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor .alpha. within Pseudomonas exotoxin as a targeting ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor .alpha. at different locations in Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Biotechnological and gene therapeutic strategies in cancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Targeted inhibition of tumour cell growth by a bispecific single-chain toxin containing an antibody domain and TGF alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A bivalent single-chain antibody-toxin specific for ErbB-2 and the EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxicity of chimeric (human-murine) monoclonal antibody BR96 IgG, F(ab')2, and Fab' conjugated to Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

The mitotoxin, basic fibroblast growth factor-saporin, effectively targets human prostatic carcinoma in an animal model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic activity of a diptheria toxin/FGF6 mitotoxin on human tumour cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Targeting plant toxins to the urokinase and alpha 2-macroglobulin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Production, characterization and cytotoxic properties of a diphtheria toxin-ciliary neurotrophic factor fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Synthesis, cytotoxic properties and effects on early and late gene induction of a chimeric diphtheria toxin-leukemia-inhibitory factor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Selective cytotoxic effects of a ricin A chain immunotoxin made with the monoclonal antibody SWA11 recognising a human small cell lung cancer antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Cytotoxic properties of a ricin A chain immunotoxin recognising the cluster-5A antigen associated with human small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Anti-tumor activity of a blocked ricin immunotoxin with specificity against the cluster-5A antigen associated with human small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

An anti-mucin immunotoxin BrE-3-ricin A-chain is potently and selectively toxic to human small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Potentiation of a weakly active ricin A chain immunotoxin recognizing the neural cell adhesion molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Elimination of neuroblastoma and small-cell lung cancer cells with an anti-neural cell adhesion molecule immunotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Immunotoxin therapy of small-cell lung cancer. N901-blocked ricin for relapsed small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Immunotoxin therapy of small-cell lung cancer: a phase I study of N901-blocked ricin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Use of the immunotoxin N901-blocked ricin in patients with small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Pharmacokinetics, tissue distribution, and in vivo antitumor effects of the antimelanoma immunotoxin ZME-gelonin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Comparison of multiple anti-CEA immunotoxins active against human adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

The synovial membrane, liver, and tongue: target organs for a ricin A-chain immunotoxin (ZD0490)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Characterization of immunotoxins active against ovarian cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Phase I Study of an Anti-Breast Cancer Immunotoxin by Continuous Infusion: Report of a Targeted Toxic Effect Not Predicted by Animal Studies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Suppression of human corneal epithelial proliferation with breast carcinoma immunotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Toxicity of ribosome-inactivating proteins-containing immunotoxins to a human bladder carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Vascular targeting--a new approach to the therapy of solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900094-X

7 January 2021

10.1016/S0169-409X(97)00094-X

Identifiers

DOI

1 reference

3 August 2017

1 reference