(Q34649069)

3 August 2017

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title

Chemical space navigation in lead discovery (English)

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3 August 2017

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Tudor I Oprea

1

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publication date

1 June 2002

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Current Opinion in Chemical Biology

3 August 2017

published in

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3 August 2017

volume

6

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3 August 2017

issue

3

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3 August 2017

page(s)

384-389

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Parallel personal comments on "classical" papers in combinatorial chemistry

3 August 2017

cites work

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7 January 2021

High Throughput Screening for Drug Discovery: Continually Transitioning into New Technology

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7 January 2021

Innovation in the pharmaceutical industry

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7 January 2021

Drug discovery: a historical perspective

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7 January 2021

Chemoinformatics - similarity and diversity in chemical libraries

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7 January 2021

Diverse viewpoints on computational aspects of molecular diversity.

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A fast algorithm for searching for molecules containing a pharmacophore in very large virtual combinatorial libraries

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7 January 2021

One-dimensional molecular representations and similarity calculations: methodology and validation

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7 January 2021

Implementation of a system for reagent selection and library enumeration, profiling, and design

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7 January 2021

Efficient combinatorial filtering for desired molecular properties of reaction products

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7 January 2021

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7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

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7 January 2021

Design and prioritization of plates for high-throughput screening.

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7 January 2021

Chance favors the prepared mind--from serendipity to rational drug design

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7 January 2021

Chemoinformatics: What is it and How does it Impact Drug Discovery

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7 January 2021

Chemoinformatics--a new name for an old problem?

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7 January 2021

Neighborhood behavior: a useful concept for validation of "molecular diversity" descriptors

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7 January 2021

GRid-INdependent descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descriptors.

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7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

Molecular complexity and its impact on the probability of finding leads for drug discovery

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7 January 2021

Is there a difference between leads and drugs? A historical perspective

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7 January 2021

Prospective identification of biologically active structures by topomer shape similarity searching

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7 January 2021

Dbtop: topomer similarity searching of conventional structure databases

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7 January 2021

Toward general methods of targeted library design: topomer shape similarity searching with diverse structures as queries

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7 January 2021

High-speed combinatorial synthesis utilizing microwave irradiation

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Beyond mere diversity: tailoring combinatorial libraries for drug discovery

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7 January 2021

Chemography: the art of navigating in chemical space.

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7 January 2021

A New Set of Principal Properties for Heteroaromatics Obtained by GRID

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7 January 2021

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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7 January 2021

New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acids

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7 January 2021

Enhancing the hit-to-lead properties of lead optimization libraries

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7 January 2021

Virtual Screening in Lead Discovery: A Viewpoint

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7 January 2021

Predicting blood-brain barrier permeation from three-dimensional molecular structure.

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Pharmacokinetically based mapping device for chemical space navigation

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7 January 2021

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Identifiers

DOI

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release_naz6cg34cferpa537qs5skn7im

3 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/naz6cg34cferpa537qs5skn7im

24 November 2022

mapped directly with Wikidata item

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