(Q34655500)

3 August 2017

1 reference

title

An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand (English)

1 reference

3 August 2017

Teruo Hayashi

1

1 reference

PubMed ID

18076369

3 August 2017

Tsung-Ping Su

series ordinal

2

1 reference

PubMed ID

18076369

3 August 2017

language of work or name

English

0 references

publication date

1 January 2008

1 reference

Expert Opinion on Therapeutic Targets

3 August 2017

1 reference

3 August 2017

12

1 reference

3 August 2017

1

1 reference

3 August 2017

45-58

1 reference

Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study

3 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Historical review: Opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Evidence for a multi-site model of the rat brain sigma receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Purification, molecular cloning, and expression of the mammalian sigma1-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptors: recent advances and new clinical potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Is the sigma2 receptor a histone binding protein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The sigma receptor as a ligand-regulated auxiliary potassium channel subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Characterization of the cocaine binding site on the sigma-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Molecular modeling of sigma 1 receptor ligands: a model of binding conformational and electrostatic considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The sigma receptor: evolution of the concept in neuropsychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Regulating ankyrin dynamics: Roles of sigma-1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

σ-1 Receptors (σ1Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Intracellular Dynamics of σ-1 Receptors (σ1Binding Sites) in NG108-15 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Silencing of sigma-1 receptor induces cell death in human lens cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptor ligands protect human retinal cells against oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

HIF-1alpha contributes to tumour-selective killing by the sigma receptor antagonist rimcazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl- channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Imaging sigma receptors: applications in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma receptors: potential medications development target for anti-cocaine agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Sigma1 receptor modulation of opioid analgesia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.45

21 January 2018

Identifiers

DOI

10.1517/14728222.12.1.45

1 reference

3 August 2017

1 reference

PubMed ID

18076369