(Q34657454)

English

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

scholarly article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method (English)

1 reference

Europe PubMed Central

3 August 2017

author name string

G Wilson

1

1 reference

Europe PubMed Central

3 August 2017

A Karlin

2

1 reference

Europe PubMed Central

3 August 2017

language of work or name

0 references

publication date

16 January 2001

1 reference

Europe PubMed Central

3 August 2017

number of pages

8

1 reference

based on heuristic

inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

3 August 2017

98

1 reference

Europe PubMed Central

3 August 2017

3

1 reference

Europe PubMed Central

3 August 2017

1241-1248

1 reference

Europe PubMed Central

3 August 2017

The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Functional characterization of a mutated chicken alpha7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

The location of the gate in the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Distinctions in agonist and antagonist specificity conferred by anionic residues of the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

The impact of receptor desensitization on fast synaptic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Projection structure of the nicotinic acetylcholine receptor: distinct conformations of the alpha subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

A molecular scheme for the reaction between acetylcholine and nicotinic channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Phosphorylation of the nicotinic acetylcholine receptor by protein tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Desensitization of acetylcholine receptors in BC3H-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Stratified organization of the nicotinic acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Local anaesthetics transiently block currents through single acetylcholine-receptor channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

7 July 2018

Photoaffinity labeling the torpedo nicotinic acetylcholine receptor with [(3)H]tetracaine, a nondesensitizing noncompetitive antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Role of the putative transmembrane segment M3 in gating of neuronal nicotinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Asymmetry of the Acetylcholine Channel Revealed by Quaternary Anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=14739

26 October 2018

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholine receptor channel imaged in the open state

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an "intermediate" conformational transition and evidence for positive cooperative effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the desensitization produced by acetylcholine at the motor end-plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of desensitization of acetylcholine receptors using nerve-released transmitter in the frog

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization at the frog neuromuscular junction: a biphasic process

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the structure of the nicotinic acetylcholine receptor with the hydrophobic photoreactive probes [125I]TID-BE and [125I]TIDPC/16

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and sodium-22 ion fluxes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two-component desensitization at the neuromuscular junction of the frog

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of lipids and detergents on the conformation of the nicotinic acetylcholine receptor from Torpedo californica

1 reference

https://pubmed.ncbi.nlm.nih.gov/11158624

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.031567798

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

ResearchGate publication ID

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