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Paradigms and pitfalls of yeast longevity research
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Paradigms and pitfalls of yeast longevity research
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
main subject
positive regulation of transcription, DNA-templated
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001308
chromatin organization
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001310
extrachromosomal rDNA circle
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0005728
formation of extrachromosomal circular DNA
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001311
replication of extrachromosomal circular DNA
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001312
cell aging
2 references
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001300
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0001302
author
David A. Sinclair
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
publication date
1 April 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
published in
Mechanisms of Ageing and Development
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
volume
123
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
page(s)
857-867
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
issue
8
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
cites work
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Some aspects of cell division in saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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inferred from DOI database lookup
A replication fork barrier at the 3' end of yeast ribosomal RNA genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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inferred from DOI database lookup
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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inferred from DOI database lookup
Aging, chromatin, and food restriction--connecting the dots
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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inferred from DOI database lookup
Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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Sound silencing: the Sir2 protein and cellular senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystallization and characterization of Pumilo: a novel RNA binding protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of longevity and stress resistance by Sch9 in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
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inferred from DOI database lookup
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Some aspects of cellular aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of Sir2p: the nucleolus as a compartment for silent information regulators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic pathways that regulate ageing in model organisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SGS1 is required for telomere elongation in the absence of telomerase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reproductive capacity and mode of death of yeast cells
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cardiac hypertrophy, aging and changes in cardiac ribosomal RNA gene dosage in man
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
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inferred from DOI database lookup
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
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inferred from DOI database lookup
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved regulatory system for aging
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution, stress, and longevity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a site required for DNA replication fork blocking activity in the rRNA gene cluster in Saccharomyces cerevisiae
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stability of recombinant plasmids containing the ars sequence of yeast extrachromosomal rDNA in several strains of Saccharomyces cerevisiae
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Organization of replication of ribosomal DNA in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial superoxide decreases yeast survival in stationary phase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silencing and heritable domains of gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the pea rDNA replication fork barrier: putative cis-acting and trans-acting factors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extrachromosomal circular DNA and aging cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative control of p53 by Sir2alpha promotes cell survival under stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Caloric restriction and aging: an update
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Common themes in mechanisms of gene silencing
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
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Life span of individual yeast cells
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
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The Werner syndrome protein: an update
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two paralogs involved in transcriptional silencing that antagonistically control yeast life span
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unwinding the molecular basis of the Werner syndrome
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Sir2 protein family: A novel deacetylase for gene silencing and more
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extrachromosomal rDNA circles--a cause of aging in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AGING INSACCHAROMYCES CEREVISIAE
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An unusual form of transcriptional silencing in yeast ribosomal DNA
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic instability as the primary cause of human aging
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: II. Age-dependent loss in human cerebral cortex — Hippocampal and somatosensory cortex comparison
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of life span determination in Caenorhabditis elegans
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Replication fork barriers in the Xenopus rDNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolic control and gene dysregulation in yeast aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900023-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0047-6374(02)00023-4
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
PubMed ID
12044934
1 reference
stated in
Europe PubMed Central
PubMed ID
12044934
retrieved
3 August 2017
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