(Q34669342)

3 August 2017

title

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS. (English)

1 reference

amyotrophic lateral sclerosis

3 August 2017

main subject

phase II clinical trial

0 references

1 reference

6

Merit Cudkowicz

1 reference

3 August 2017

Robert G Miller

1

1 reference

3 August 2017

Gilbert Block

2

1 reference

3 August 2017

Jonathan S Katz

3

1 reference

3 August 2017

Richard J Barohn

4

1 reference

3 August 2017

Vidhya Gopalakrishnan

5

1 reference

3 August 2017

Jane R Zhang

7

1 reference

3 August 2017

Michael S McGrath

8

1 reference

3 August 2017

Elizabeth Ludington

9

1 reference

3 August 2017

Stan H Appel

10

1 reference

3 August 2017

Ari Azhir

11

1 reference

3 August 2017

Phase 2 Trial NP001 Investigators

12

1 reference

3 August 2017

publication date

9 April 2015

1 reference

Neurology(R) neuroimmunology & neuroinflammation

3 August 2017

published in

1 reference

3 August 2017

volume

2

1 reference

3 August 2017

issue

3

1 reference

3 August 2017

page(s)

e100

1 reference

NP001 regulation of macrophage activation markers in ALS: a phase I clinical and biomarker study

3 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Motor neuron-immune interactions: the vicious circle of ALS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Microglia in ALS: the good, the bad, and the resting

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Biomarkers in amyotrophic lateral sclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

ALS: a disease of motor neurons and their nonneuronal neighbors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Differential effects on innate versus adaptive immune responses by WF10.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Development of WF10, a novel macrophage-regulating agent.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396529

Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25884010

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25884010

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1212/NXI.0000000000000100

1 reference

3 August 2017

1 reference

3 August 2017

1 reference