(Q34691239)

4 August 2017

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title

Pathologically activated therapeutics for neuroprotection (English)

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4 August 2017

Stuart A Lipton

1

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4 August 2017

language of work or name

English

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publication date

1 October 2007

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Nature Reviews Neuroscience

4 August 2017

published in

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4 August 2017

volume

8

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4 August 2017

issue

10

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4 August 2017

page(s)

803-808

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Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

4 August 2017

cites work

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Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

21 January 2018

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Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size

21 January 2018

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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

21 January 2018

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Emerging treatments for stroke in humans

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NMDA receptor pathways as drug targets

31 March 2020

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Turning down, but not off.

31 March 2020

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Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

31 March 2020

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Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state

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Neurophysiology: stressful pacemaking

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'Rejuvenation' protects neurons in mouse models of Parkinson's disease

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Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

31 March 2020

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Excitatory amino acids as a final common pathway for neurologic disorders.

31 March 2020

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Excitatory amino acid neurotoxicity and neurodegenerative disease

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Pathways towards and away from Alzheimer's disease

31 March 2020

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Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome

31 March 2020

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Pathways to neuronal injury and apoptosis in HIV-associated dementia.

31 March 2020

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New perspectives on glaucoma

31 March 2020

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

31 March 2020

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

31 March 2020

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

31 March 2020

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NMDA receptors, glial cells, and clinical medicine

31 March 2020

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The chemical biology of clinically tolerated NMDA receptor antagonists

31 March 2020

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Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A

31 March 2020

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Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain

31 March 2020

1 reference

Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain

31 March 2020

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NR3A modulates the outer vestibule of the "NMDA" receptor channel

31 March 2020

1 reference

Protein S-nitrosylation: purview and parameters

31 March 2020

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Biochemistry of Nitric Oxide and Its Redox-Activated Forms

31 March 2020

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Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

31 March 2020

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Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

31 March 2020

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A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

31 March 2020

1 reference

Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-.

31 March 2020

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Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif

31 March 2020

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

31 March 2020

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Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

31 March 2020

1 reference

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

31 March 2020

1 reference

New avenues of exploration for erythropoietin

31 March 2020

1 reference

Emerging biological roles for erythropoietin in the nervous system

31 March 2020

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Erythropoietin for neurologic protection and diabetic neuropathy

31 March 2020

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A potential role for erythropoietin in focal permanent cerebral ischemia in mice.

31 March 2020

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Erythropoietin: structure, control of production, and function

31 March 2020

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Localization of specific erythropoietin binding sites in defined areas of the mouse brain

31 March 2020

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Neurons and astrocytes express EPO mRNA: Oxygen-sensing mechanisms that involve the redox-state of the brain

31 March 2020

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Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

31 March 2020

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Erythropoietin therapy for acute stroke is both safe and beneficial

31 March 2020

1 reference

Potent mechanism-based inhibitors for matrix metalloproteinases

31 March 2020

1 reference

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

31 March 2020

1 reference

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

31 March 2020

1 reference

Metalloproteinases in biology and pathology of the nervous system.

31 March 2020

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Metalloproteinases: mediators of pathology and regeneration in the CNS.

31 March 2020

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Extracellular matrix degradation by metalloproteinases and central nervous system diseases

31 March 2020

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Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.

31 March 2020

1 reference

Matrix metalloproteinases and free radicals in cerebral ischemia

31 March 2020

1 reference

Matrix metalloproteinases and their inhibitors in the nervous system: the good, the bad and the enigmatic

31 March 2020

1 reference

Matrix Metalloproteinase Expression After Human Cardioembolic Stroke

31 March 2020

1 reference

Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.

31 March 2020

1 reference

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.

31 March 2020

1 reference

Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction

31 March 2020

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Matrix metalloproteinases increase very early during experimental focal cerebral ischemia

31 March 2020

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Role of matrix metalloproteinases in delayed cortical responses after stroke

31 March 2020

1 reference

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers

31 March 2020

1 reference

Redox regulation of neuronal survival mediated by electrophilic compounds

31 March 2020

1 reference

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

31 March 2020

1 reference

Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

31 March 2020

1 reference

A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.

31 March 2020

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Molecular mechanisms of local anesthesia: a review

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN2229

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Dimensions Publication ID

4 August 2017

1025114625

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