(Q34695795)

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Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly.

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Europe PubMed Central

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19 January 2020

Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly (English)

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19 January 2020

influenza A virus

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influenza A virus

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Stephane Boivin

1

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19 January 2020

2

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19 January 2020

author name string

Stephane Boivin

1

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4 August 2017

Darren J Hart

2

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4 August 2017

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publication date

7 January 2011

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19 January 2020

Journal of Biological Chemistry

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19 January 2020

286

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19 January 2020

12

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19 January 2020

10439-10448

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21216958%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin- Using Oriented Peptide Library Screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Adaptive strategies of the influenza virus polymerase for replication in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Identifying changes in selective constraints: host shifts in influenza.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Different evolutionary trajectories of European avian-like and classical swine H1N1 influenza A viruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Selection of H5N1 influenza virus PB2 during replication in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Host restriction of avian influenza viruses at the level of the ribonucleoproteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The structural basis for cap binding by influenza virus polymerase subunit PB2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Persistent host markers in pandemic and H5N1 influenza viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Differential polymerase activity in avian and mammalian cells determines host range of influenza virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Genomic signatures of human versus avian influenza A viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

How do biomolecular systems speed up and regulate rates?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The long-range electrostatic interactions control tRNA-aminoacyl-tRNA synthetase complex formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Biophysical characterization of interactions involving importin-alpha during nuclear import

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Sialic acid species as a determinant of the host range of influenza A viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Nuclear targeting signal recognition: a key control point in nuclear transport?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Transport of proteins and RNAs in and out of the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Nuclear import and export of influenza virus nucleoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The molecular anatomy of influenza virus RNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Brownian dynamics study of the influences of electrostatic interaction and diffusion on protein-protein association kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

7 July 2018

Influenza virus virulence and its molecular determinants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Efficiency of importin alpha/beta-mediated nuclear localization sequence recognition and nuclear import. Differential role of NTF2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182964

21 January 2018

Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060497

26 October 2018

Quantitative analysis of nuclear localization signal (NLS)-importin alpha interaction through fluorescence depolarization. Evidence for auto-inhibitory regulation of NLS binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21216958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization signal receptor affinity correlates with in vivo localization in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/21216958

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.182964

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21216958%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21216958%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21216958%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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