(Q34699424)

4 August 2017

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title

Genetics of Parkinson's disease and biochemical studies of implicated gene products (English)

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4 August 2017

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2

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author name string

Peter T Lansbury

series ordinal

1

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4 August 2017

1 June 2002

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Current Opinion in Genetics & Development

4 August 2017

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4 August 2017

12

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4 August 2017

299-306

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4 August 2017

3

1 reference

New animal models for Parkinson's disease

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr ?-synuclein mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

alpha-synuclein gene haplotypes are associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Membrane binding and self-association of alpha-synucleins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Genetic Analysis of Synphilin-1 in Familial Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Cytosolic O-glycosylation is abundant in nerve terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

The parkin gene is not involved in late-onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

New mutation (R42P) of the parkin gene in the ubiquitinlike domain associated with parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Complex relationship between Parkin mutations and Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Parkin gene causing benign autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Homozygous deletion mutation of the parkin gene in patients with atypical parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

The parkin gene and its phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Pseudo-dominant inheritance and exon 2 triplication in a family with parkin gene mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Parkin and Parkinson's: more than homonymy?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

PARK6-linked parkinsonism occurs in several European families.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Genome-wide scan for Parkinson's disease: the GenePD Study

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Complete genomic screen in Parkinson disease: evidence for multiple genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

The tau A0 allele in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Case-control study of the extended tau gene haplotype in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

Tau and Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900302-7

7 January 2021

10.1016/S0959-437X(02)00302-7

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12076673