(Q34700142)

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Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

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8 January 2020

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity (English)

1 reference

Europe PubMed Central

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8 January 2020

Caenorhabditis elegans

0 references

Huntington interacting protein related 1 CELE_ZK370.3

1 reference

GOA release 2020-03-11

1

1 reference

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8 January 2020

3

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8 January 2020

Michael R. Hayden

7

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8 January 2020

8

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8 January 2020

author name string

Martina Metzler

2

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8 January 2020

Marilyne Mage

4

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8 January 2020

John C Roder

5

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8 January 2020

Ann M Rose

6

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8 January 2020

language of work or name

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publication date

1 October 2007

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8 January 2020

Journal of Neuroscience

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8 January 2020

27

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8 January 2020

11056-11064

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8 January 2020

41

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8 January 2020

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficits in memory and motor performance in synaptotagmin IV mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synaptic vesicle cycle revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium: the common theme in vesicular cycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice transgenic for exon 1 of Huntington's disease: properties of cholinergic and dopaminergic pre-synaptic function in the striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptobrevin is essential for fast synaptic-vesicle endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic analysis of genes required for synapse structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA microarray analysis of striatal gene expression in symptomatic transgenic Huntington's mice (R6/2) reveals neuroinflammation and insulin associations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors regulating the abundance and localization of synaptobrevin in the plasma membrane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel function of clathrin light chain in promoting endocytic vesicle formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1−/− mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The corticostriatal pathway in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal Structure at 2.8 Å of the DLLRKN-containing Coiled-coil Domain of Huntingtin-interacting Protein 1 (HIP1) Reveals a Surface Suitable for Clathrin Light Chain Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting coiled coils from protein sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis of defecation in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate receptor-mediated inhibition of presynaptic Ca2+ influx and EPSP in area CA1 of the rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/17928447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1941-07.2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17928447%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17928447%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17928447%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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