(Q34704137)

4 August 2017

title

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis (English)

1 reference

4 August 2017

main subject

Caenorhabditis elegans

0 references

1 reference

James R Johnson

3

0 references

Alan Morgan

object named as

Alan Morgan

7

0 references

Jeff W Barclay

object named as

Jeff W Barclay

9

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author name string

Margaret E Graham

1

1 reference

4 August 2017

Gerald R Prescott

2

1 reference

4 August 2017

Mathew Jones

4

1 reference

4 August 2017

Alice Walmesley

5

1 reference

4 August 2017

Lee P Haynes

6

1 reference

4 August 2017

Robert D Burgoyne

8

1 reference

4 August 2017

language of work or name

English

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publication date

21 March 2011

1 reference

4 August 2017

1 reference

4 August 2017

volume

6

1 reference

4 August 2017

issue

3

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4 August 2017

page(s)

e17999

1 reference

Creative Commons Attribution 4.0 International

4 August 2017

copyright license

start time

21 March 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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1 reference

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Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

7 July 2018

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7 July 2018

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SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.

7 July 2018

1 reference

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Mso1p regulates membrane fusion through interactions with the putative N-peptide-binding area in Sec1p domain 1.

7 July 2018

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Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle

7 July 2018

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Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells

7 July 2018

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Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

7 July 2018

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Membrane fusion: grappling with SNARE and SM proteins

7 July 2018

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The functions of Munc18-1 in regulated exocytosis

7 July 2018

1 reference

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UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans

7 July 2018

1 reference

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A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins

7 July 2018

1 reference

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UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin

7 July 2018

1 reference

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Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

7 July 2018

1 reference

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Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus

7 July 2018

1 reference

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Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

7 July 2018

1 reference

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Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.

7 July 2018

1 reference

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Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins

7 July 2018

1 reference

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Munc18-1 binds directly to the neuronal SNARE complex

7 July 2018

1 reference

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Functionally and spatially distinct modes of munc18-syntaxin 1 interaction

7 July 2018

1 reference

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Selective activation of cognate SNAREpins by Sec1/Munc18 proteins

7 July 2018

1 reference

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SNAREs--engines for membrane fusion

7 July 2018

1 reference

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The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Electrochemical imaging of fusion pore openings by electrochemical detector arrays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Multiple SNARE interactions of an SM protein: Sed5p/Sly1p binding is dispensable for transport

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Defects in synaptic vesicle docking in unc-18 mutants

7 July 2018

1 reference

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Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Munc18-1 promotes large dense-core vesicle docking

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Crystal structures of neuronal squid Sec1 implicate inter-domain hinge movement in the release of t-SNAREs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Mints as adaptors. Direct binding to neurexins and recruitment of munc18

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

nSec1 binds a closed conformation of syntaxin1A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

A conformational switch in syntaxin during exocytosis: role of munc18.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

SNAREpins: minimal machinery for membrane fusion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Mints, Munc18-interacting proteins in synaptic vesicle exocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Pentapeptide scanning mutagenesis: random insertion of a variable five amino acid cassette in a target protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

The genetics of Caenorhabditis elegans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

A protein-protein binding assay using coated microtitre plates: increased throughput, reproducibility and speed compared to bead-based assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

Munc-18-1 regulates the initial release rate of exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061876

[28] Linker insertion mutagenesis as probe of structure-function relationships

26 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017999

Measurement of exocytosis by amperometry in adrenal chromaffin cells: effects of clostridial neurotoxins and activation of protein kinase C on fusion pore kinetics

21 January 2018

1 reference

12 December 2020

Control of fusion pore dynamics during exocytosis by Munc18

1 reference

12 December 2020

Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13

1 reference

12 December 2020

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0017999

Identifiers

DOI

1 reference

4 August 2017

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4 August 2017

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