(Q34713118)

4 August 2017

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title

The disparity between human cell senescence in vitro and lifelong replication in vivo (English)

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4 August 2017

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Harry Rubin

1

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4 August 2017

publication date

1 July 2002

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4 August 2017

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4 August 2017

volume

20

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4 August 2017

issue

7

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4 August 2017

page(s)

675-681

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The serial cultivation of human diploid cell strains

4 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNBT0702-675

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Cell aging in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Variation in the life-span of clones derived from human diploid cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Regulation of human fibroblast growth rate by both noncycling cell fraction transition probability is shown by growth in 5-bromodeoxyuridine followed by Hoechst 33258 flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

A quantitative analysis of the aging of human glial cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Comparison of doubling numbers attained by cultured animal cells with life span of species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Age and the generation time of the mouse duodenal epithelial cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Caloric Restriction: Conservation of Cellular Replicative Capacity in Vitro Accompanies Life-Span Extension in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

The relationship between in vitro cellular aging and in vivo human age

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere end-replication problem and cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

The telomere hypothesis of cellular aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere states and cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Human endothelial cell life extension by telomerase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Cellular senescence: mitotic clock or culture shock?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Lack of replicative senescence in normal rodent glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase and cellular lifespan: ending the debate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Developmental and tissue-specific regulation of mouse telomerase and telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase activity in normal and malignant hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase regulation during entry into the cell cycle in normal human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase activity: a biomarker of cell proliferation, not malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Stem cell patterning and fate in human epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase activity, cell proliferation, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

The rate of telomere sequence loss in human leukocytes varies with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomerase, Cell Immortality, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Multiple pathways for the regulation of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Frequent clones of p53-mutated keratinocytes in normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Clone size variation in the human diploid cell strain, wi-38

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

The two-stage mechanism controlling cellular senescence and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomeres and senescence: ending the debate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Wild-derived inbred mouse strains have short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Morphologic changes accompanying senescence of cultured human diploid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Does oxidative damage to DNA increase with age?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Effect of age on lymphocyte proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Cell Proliferation and Renewal in Aging Mice

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Aging. When do telomeres matter?

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomerase activity concentrates in the mitotically active segments of human hair follicles

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Enzyme patterns in cultured kidney cells

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomere shortening during aging of human osteoblasts in vitro and leukocytes in vivo: lack of excessive telomere loss in osteoporotic patients

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Clonal variation and aging of diploid fibroblasts. Cinematographic studies of cell pedigrees

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Identifiers

DOI

10.1038/NBT0702-675

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4 August 2017

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