(Q34713118)

4 August 2017

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title

The disparity between human cell senescence in vitro and lifelong replication in vivo (English)

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4 August 2017

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Harry Rubin

1

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4 August 2017

1 July 2002

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4 August 2017

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4 August 2017

20

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4 August 2017

675-681

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4 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nbt0702-675

4 August 2017

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21 January 2018

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Regulation of human fibroblast growth rate by both noncycling cell fraction transition probability is shown by growth in 5-bromodeoxyuridine followed by Hoechst 33258 flow cytometry

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

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Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

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21 January 2018

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

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Telomerase activity: a biomarker of cell proliferation, not malignant transformation

21 January 2018

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Stem cell patterning and fate in human epidermis

21 January 2018

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Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

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Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis

21 January 2018

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Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart

21 January 2018

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Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture

21 January 2018

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

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Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

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21 January 2018

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Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations

21 January 2018

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Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

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Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita

21 January 2018

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

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Telomerase, cell immortality, and cancer

21 January 2018

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Multiple pathways for the regulation of telomerase activity

21 January 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

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Frequent clones of p53-mutated keratinocytes in normal human skin

21 January 2018

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Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

21 January 2018

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Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

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Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

21 January 2018

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21 January 2018

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Clone size variation in the human diploid cell strain, wi-38

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

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Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

21 January 2018

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Wild-derived inbred mouse strains have short telomeres

21 January 2018

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Morphologic changes accompanying senescence of cultured human diploid cells

21 January 2018

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Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

21 January 2018

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Does oxidative damage to DNA increase with age?

21 January 2018

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21 January 2018

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Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Effect of age on lymphocyte proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Cell Proliferation and Renewal in Aging Mice

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

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https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Aging. When do telomeres matter?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomerase activity concentrates in the mitotically active segments of human hair follicles

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Enzyme patterns in cultured kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Telomere shortening during aging of human osteoblasts in vitro and leukocytes in vivo: lack of excessive telomere loss in osteoporotic patients

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Clonal variation and aging of diploid fibroblasts. Cinematographic studies of cell pedigrees

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-675

7 January 2021

Identifiers

DOI

10.1038/NBT0702-675

1 reference

4 August 2017

1 reference

PubMed ID

12089551