(Q34718125)

4 August 2017

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title

Selection and fine-tuning of the autoimmune T-cell repertoire (English)

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4 August 2017

Stephen M Anderton

1

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4 August 2017

David C Wraith

series ordinal

2

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4 August 2017

publication date

1 July 2002

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Nature Reviews Immunology

4 August 2017

published in

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4 August 2017

volume

2

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4 August 2017

issue

7

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4 August 2017

page(s)

487-498

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The enemy within: keeping self-reactive T cells at bay in the periphery

4 August 2017

cites work

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Negative selection during the peripheral immune response to antigen

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Role of CD4 in thymocyte selection and maturation

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Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression

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pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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Fine tuning of TCR signaling by CD5.

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A very high level of crossreactivity is an essential feature of the T-cell receptor

31 March 2020

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Evidence for a differential avidity model of T cell selection in the thymus

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Selection of the T cell repertoire.

31 March 2020

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A kinetic window constricts the T cell receptor repertoire in the thymus.

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T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

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Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein

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Endogenous myelin basic protein inactivates the high avidity T cell repertoire

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

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Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin

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Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance

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Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells

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Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

31 March 2020

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Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft

31 March 2020

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A new look at MHC and autoimmune disease

31 March 2020

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T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

31 March 2020

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Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice

31 March 2020

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T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

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Influence of a dominant cryptic epitope on autoimmune T cell tolerance

31 March 2020

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An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

31 March 2020

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Control of antigen presentation by a single protease cleavage site

31 March 2020

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Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

31 March 2020

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Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses

31 March 2020

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Autoreactivity, dynamic tuning and selectivity

31 March 2020

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

31 March 2020

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Mature T cell reactivity altered by peptide agonist that induces positive selection

31 March 2020

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T cell receptor antagonist peptides induce positive selection

31 March 2020

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Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

31 March 2020

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Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigens

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Selecting and maintaining a diverse T-cell repertoire

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Homeostasis of alpha beta TCR+ T cells.

31 March 2020

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

31 March 2020

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Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells

31 March 2020

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Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

31 March 2020

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Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

31 March 2020

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Nonclassical MHC class II molecules

31 March 2020

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Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

31 March 2020

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Antigen presentation and T cell development in H2-M-deficient mice

31 March 2020

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Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation

31 March 2020

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The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

31 March 2020

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CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

31 March 2020

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Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding

31 March 2020

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CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1

31 March 2020

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Sensory adaptation in naive peripheral CD4 T cells

31 March 2020

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Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells

31 March 2020

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Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

31 March 2020

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Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

31 March 2020

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Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

31 March 2020

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A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis

31 March 2020

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Ligand recognition by alpha beta T cell receptors

31 March 2020

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Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity

31 March 2020

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A kinetic basis for T cell receptor repertoire selection during an immune response

31 March 2020

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T cell affinity maturation by selective expansion during infection

31 March 2020

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T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo

31 March 2020

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An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro

31 March 2020

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The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope

31 March 2020

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Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318

31 March 2020

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Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

31 March 2020

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T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

31 March 2020

1 reference

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

31 March 2020

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Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

31 March 2020

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Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice

31 March 2020

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Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity

31 March 2020

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T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity

31 March 2020

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Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

31 March 2020

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

31 March 2020

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The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells

31 March 2020

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

31 March 2020

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Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

31 March 2020

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In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis

31 March 2020

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Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis

31 March 2020

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Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands

31 March 2020

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Antigen-presenting cell activation: a link between infection and autoimmunity?

31 March 2020

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How can dendritic cells cause autoimmune disease?

31 March 2020

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In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen.

31 March 2020

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Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.

31 March 2020

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Post-translational protein modifications in antigen recognition and autoimmunity

31 March 2020

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Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

31 March 2020

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Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

31 March 2020

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Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

31 March 2020

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Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

31 March 2020

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Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities

31 March 2020

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31 March 2020

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On the relationship between viral infection and autoimmunity.

31 March 2020

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Molecular mimicry and autoimmunity.

31 March 2020

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

31 March 2020

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

31 March 2020

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Expression of two T cell receptor alpha chains: dual receptor T cells

31 March 2020

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Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI842

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4 August 2017

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