(Q34718730)

4 August 2017

title

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance (English)

1 reference

4 August 2017

0 references

1 reference

1 reference

Yunkyoung Lee

2

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Michael J. Jurczak

object named as

Michael J Jurczak

5

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Gerald I. Shulman

object named as

Gerald I Shulman

3

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Varman T Samuel

4

object named as

Varman T Samuel

1 reference

4 August 2017

James W Perfield

1

1 reference

4 August 2017

Eugene Chang

6

1 reference

4 August 2017

Chen Xie

7

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4 August 2017

Phillip N Tsichlis

8

1 reference

4 August 2017

Martin S Obin

9

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4 August 2017

Andrew S Greenberg

10

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4 August 2017

language of work or name

English

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publication date

23 February 2011

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4 August 2017

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4 August 2017

volume

60

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4 August 2017

issue

4

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4 August 2017

page(s)

1168-1176

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

4 August 2017

copyright license

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

7 July 2018

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Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance

7 July 2018

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7 July 2018

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Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

7 July 2018

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Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis

7 July 2018

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Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus

7 July 2018

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7 July 2018

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7 July 2018

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JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

7 July 2018

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Salsalate improves glycemia and inflammatory parameters in obese young adults

7 July 2018

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A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

7 July 2018

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Metabolic endotoxemia initiates obesity and insulin resistance

7 July 2018

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Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

7 July 2018

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Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

7 July 2018

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

7 July 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

7 July 2018

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ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

7 July 2018

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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

7 July 2018

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Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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IKK-beta links inflammation to obesity-induced insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

IkappaB kinase is an essential component of the Tpl2 signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

7 July 2018

1 reference

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

7 July 2018

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Obesity is associated with macrophage accumulation in adipose tissue

7 July 2018

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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

7 July 2018

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A central role for JNK in obesity and insulin resistance

7 July 2018

1 reference

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Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

7 July 2018

1 reference

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7 July 2018

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

7 July 2018

1 reference

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Kupffer cell activation is a causal factor for hepatic insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Evaluating the glucose tolerance test in mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

A simple and rapid method to assay triacylglycerol in cells and tissues.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064090

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study

9 December 2018

1 reference

12 December 2020

Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity

1 reference

12 December 2020

Adipocyte death, adipose tissue remodeling, and obesity complications

1 reference

12 December 2020

Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB10-0715

1 reference

4 August 2017

1 reference

4 August 2017

1 reference