(Q34719875)

4 August 2017

title

Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor (English)

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4 August 2017

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Briony E Forbes

6

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Pierre De Meyts

object named as

Pierre De Meyts

7

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author name string

Lisbeth Gauguin

1

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4 August 2017

Birgit Klaproth

2

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4 August 2017

Waseem Sajid

3

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4 August 2017

Asser S Andersen

4

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4 August 2017

Kerrie A McNeil

5

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4 August 2017

language of work or name

English

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publication date

29 November 2007

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Journal of Biological Chemistry

4 August 2017

published in

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4 August 2017

volume

283

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4 August 2017

issue

5

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4 August 2017

page(s)

2604-2613

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Sequence of the human insulin gene

4 August 2017

cites work

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Molecular interactions of the IGF system

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Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

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Alternative splicing of human insulin receptor messenger RNA.

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Insulin interactions with its receptors: experimental evidence for negative cooperativity.

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Structural biology of insulin and IGF1 receptors: implications for drug design

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Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

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Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

21 January 2018

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 January 2018

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A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor

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Expression of insulin in yeast: the importance of molecular adaptation for secretion and conversion

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Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu 3, following their expression in Escherichia coli as fusion proteins

21 January 2018

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Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II.

21 January 2018

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Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

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Mutations in the B-domain of insulin-like growth factor-I influence the oxidative folding to yield products with modified biological properties

21 January 2018

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Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site

21 January 2018

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Receptor-binding region of insulin

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Structure of the insulin receptor ectodomain reveals a folded-over conformation

21 January 2018

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The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

21 January 2018

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Insulin receptor structure and its implications for the IGF-1 receptor

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Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor

21 January 2018

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Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

21 January 2018

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Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation

21 January 2018

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Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin

21 January 2018

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Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

21 January 2018

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The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis

21 January 2018

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Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues

21 January 2018

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Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer

21 January 2018

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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

1 reference

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A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II

21 January 2018

1 reference

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Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709220200

21 January 2018

Identifiers

DOI

10.1074/JBC.M709220200

1 reference

4 August 2017

1 reference