(Q34722249)

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Targeting anti-apoptotic genes upregulated by androgen withdrawal using antisense oligonucleotides to enhance androgen- and chemo-sensitivity in prostate cancer

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Europe PubMed Central

PubMed publication ID

4 August 2017

1 reference

Europe PubMed Central

Targeting anti-apoptotic genes upregulated by androgen withdrawal using antisense oligonucleotides to enhance androgen- and chemo-sensitivity in prostate cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Martin E Gleave

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Toby Zellweger

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Kim Chi

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Hideaki Miyake

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Satoshi Kiyama

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Laura July

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Simon Leung

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

publication date

1 May 2002

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

145-158

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Active cell death in hormone-dependent tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LNCaP cell line--a new model for studies on human prostatic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin: Physiologic and pathophysiologic considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of phase III trials on combined androgen treatment in patients with metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostatic involution in men taking finasteride is associated with elevated levels of insulin-like growth factor-binding proteins (IGFBPs)-2, -4, and -5

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3'-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of association between enhanced TRPM-2/clusterin expression and increased apoptotic activity in sex-hormone-induced prostatic dysplasia of the Noble rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen-repressed messages in the rat ventral prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin: a role in cell survival in the face of apoptosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced transcription of the clusterin/apoJ gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin and the kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of clusterin in human breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic Applications of Oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical Analysis of Radical Prostatectomy Specimens After 8 Months of Neoadjuvant Hormonal Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgenic Induction of Prostate-specific Antigen Gene Is Repressed by Protein-Protein Interaction between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein J (clusterin) and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of prostate cancer to anti-Her-2/neu antibody in androgen-dependent and -independent human xenograft models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IGF axis in the prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors and their binding proteins: biological actions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl2 is the guardian of microtubule integrity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of docetaxel with estramustine in androgen-independent prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of 96-hour paclitaxel plus oral estramustine phosphate in metastatic hormone-refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel androgen-sensitive, prostate-specific antigen-producing prostatic carcinoma xenograft: LuCaP 23.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of hormone refractory prostate cancer: current standards and future prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin is a secreted mammalian chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the human androgen receptor through a protein kinase A signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12099575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1015694802521

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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