(Q34724245)

4 August 2017

title

Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA. (English)

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4 August 2017

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1

Douglas Melton

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4 August 2017

Calvin D Lewis

2

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4 August 2017

Nathan E Price

series ordinal

3

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4 August 2017

Kent S Gates

series ordinal

4

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4 August 2017

publication date

18 November 2014

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Chemical Research in Toxicology

4 August 2017

published in

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4 August 2017

volume

27

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4 August 2017

issue

12

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4 August 2017

page(s)

2113-2118

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Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH.

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Importance of ortho proton donors in catalysis of hydrazone formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Rapid catalyst-free hydrazone ligation: protein-pyridoxal phosphoramides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Older blood pressure medications-do they still have a place?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

How to manage hypertension in pregnancy effectively

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

DNA hypermethylation as a chemotherapy target

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Active DNA demethylation: many roads lead to Rome.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Reversible site-specific tagging of enzymatically synthesized RNAs using aldehyde-hydrazine chemistry and protease-cleavable linkers.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Biologically relevant chemical reactions of N7-alkylguanine residues in DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Endogenous DNA damage in humans: a review of quantitative data

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

DNA adducts, mutations and cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Hydralazine and other hydrazine derivatives and the formation of DNA adducts.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

DNA adducts of chemical carcinogens

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Possible roles of beta-elimination and delta-elimination reactions in the repair of DNA containing AP (apurinic/apyrimidinic) sites in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Evidence for AP site formation related to DNA-oxygen alkylation in CHO cells treated with ethylating agents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Hydralazine target: from blood vessels to the epigenome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269403

Stability studies of hydralazine hydrochloride in aqueous solutions

26 October 2018

1 reference

12 December 2020

Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines

1 reference

12 December 2020

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity

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12 December 2020

Target watch: Drugging the epigenome

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12 December 2020

Enzymatic activation of hydrazine derivatives. A spin-trapping study

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12 December 2020

Peroxidase substrates stimulate the oxidation of hydralazine to metabolites which cause single-strand breaks in DNA

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12 December 2020

Clinical use of hydralazine and hexamethonium in treatment of hypertension

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12 December 2020

Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

1 reference

12 December 2020

Plasma concentration and acetylator phenotype determine response to oral hydralazine

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12 December 2020

Free radical production and site-specific DNA damage induced by hydralazine in the presence of metal ions or peroxidase/ hydrogen peroxide

1 reference

12 December 2020

Hydralazine-pyrimidine interactions may explain hydralazine-induced lupus erythematosus

1 reference

12 December 2020

Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter

1 reference

12 December 2020

Detection of oxidative mutagenesis by isoniazid and other hydrazine derivatives in Escherichia coli WP2 tester strain IC203, deficient in OxyR: strong protective effects of rat liver S9

1 reference

12 December 2020

Specificities and kinetics of uracil excision from uracil-containing DNA oligomers by Escherichia coli uracil DNA glycosylase

1 reference

12 December 2020

Reaction of apurinic acid with aldehyde reagents

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12 December 2020

Identifiers

DOI

10.1021/TX5003657

1 reference

4 August 2017

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4 August 2017

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