(Q34725737)

4 August 2017

1 reference

title

Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs (English)

1 reference

4 August 2017

1 reference

1 reference

1 reference

Reza Mehvar

1

1 reference

4 August 2017

Dion R Brocks

series ordinal

2

1 reference

4 August 2017

Majid Vakily

series ordinal

3

1 reference

4 August 2017

publication date

1 January 2002

1 reference

Clinical Pharmacokinetics

4 August 2017

published in

1 reference

4 August 2017

volume

41

1 reference

4 August 2017

issue

8

1 reference

4 August 2017

page(s)

533-558

1 reference

https://scigraph.springernature.com/pub.10.2165/00003088-200241080-00001

4 August 2017

exact match

0 references

cites work

Single- and multiple-dose pharmacokinetics of R-(-)-and S-(+)-prenylamine in man.

1 reference

12 December 2020

Serum binding of tocainide and its enantiomers in human subjects.

1 reference

12 December 2020

Input rate-dependent stereoselective pharmacokinetics: effect of pulsatile oral input

1 reference

12 December 2020

Comparative pharmacokinetics and clinical pharmacology of propafenone enantiomers after oral administration to man

1 reference

12 December 2020

Relationship between the stereoselective negative inotropic effects of verapamil enantiomers and their binding to putative calcium channels in human heart

1 reference

12 December 2020

Stereoselective disposition of the antiarrhythmic agent mexiletine during the concomitant administration of caffeine

1 reference

12 December 2020

Resolution of flecainide acetate, N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzam ide acetate, and antiarrhythmic properties of the enantiomers

1 reference

12 December 2020

Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil

1 reference

12 December 2020

Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism

1 reference

12 December 2020

Enantioselective determination of diprafenone in human plasma

1 reference

12 December 2020

Pharmacokinetics of mexiletine enantiomers in healthy human subjects. A study of the in vivo serum protein binding, salivary excretion and red blood cell distribution of the enantiomers

1 reference

12 December 2020

The effects of the stereoisomers of propafenone and diprafenone in guinea-pig heart

1 reference

12 December 2020

Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers.

1 reference

12 December 2020

Stereoselective protein binding of verapamil enantiomers

1 reference

12 December 2020

Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers

1 reference

12 December 2020

Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: the role of plasma protein binding

1 reference

12 December 2020

Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration

1 reference

12 December 2020

Comparative pharmacokinetics of unbound disopyramide enantiomers following oral administration of racemic disopyramide in humans

1 reference

12 December 2020

Pharmacokinetics of verapamil and norverapamil enantiomers after administration of immediate and controlled-release formulations to humans:evidence suggesting input-rate determined stereoselectivity

1 reference

12 December 2020

An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy

1 reference

12 December 2020

Food increases the bioavailability of propafenone

1 reference

12 December 2020

Verapamil stereoisomerism: enantiomeric ratios in plasma dependent on peak concentrations, oral input rate, or both.

1 reference

12 December 2020

Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias

1 reference

12 December 2020

Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans.

1 reference

12 December 2020

Protein binding of propranolol and verapamil enantiomers in maternal and foetal serum

1 reference

12 December 2020

The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans

1 reference

12 December 2020

Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.

1 reference

12 December 2020

Stereoselective hydroxylation of mexiletine in human liver microsomes: implication of P450IID6--a preliminary report

1 reference

12 December 2020

Absorption and disposition of a new antiarrhythmic agent bidisomide in man

1 reference

12 December 2020

Stereoselective serum protein binding of mexiletine enantiomers in man

1 reference

12 December 2020

Stereoselective and nonstereoselective inhibition exhibited by the enantiomers of verapamil.

1 reference

12 December 2020

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interaction between mexiletine and propafenone in human beings

1 reference

12 December 2020

Tissue distribution of mexiletine enantiomers in rats.

1 reference

12 December 2020

Input rate-dependent stereoselective pharmacokinetics: enantiomeric oral bioavailability and blood concentration ratios after constant oral input

1 reference

12 December 2020

Enantioselective binding analysis of verapamil to plasma lipoproteins by capillary electrophoresis-frontal analysis

1 reference

12 December 2020

Stereoselective metabolism and pharmacokinetics of disopyramide enantiomers in humans

1 reference

12 December 2020

Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans

1 reference

12 December 2020

No effect of high-protein food on the stereoselective bioavailability and pharmacokinetics of verapamil

1 reference

12 December 2020

Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Stereoselectivity in central analgesic action of tocainide and its analogs.

1 reference

12 December 2020

The absence of stereoselective P-glycoprotein-mediated transport of R/S-verapamil across the rat jejunum

1 reference

12 December 2020

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites

1 reference

12 December 2020

Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine metaboliser phenotype

1 reference

12 December 2020

Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique

1 reference

12 December 2020

Serum tocainide enantiomer concentrations in human subjects

1 reference

12 December 2020

Apparent stereoselectivity in propafenone uptake by human and rat erythrocytes

1 reference

12 December 2020

Pharmacokinetics of pirmenol enantiomers and pharmacodynamics of pirmenol racemate in patients with premature ventricular contractions

1 reference

12 December 2020

Stereoselective pharmacokinetics of disopyramide enantiomers in man

1 reference

12 December 2020

Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes.

1 reference

12 December 2020

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action

1 reference

12 December 2020

In vivo interaction of the enantiomers of disopyramide in human subjects

1 reference

12 December 2020

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects

1 reference

12 December 2020

Stereoselective pharmacokinetics of disopyramide and interaction with cimetidine

1 reference

12 December 2020

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1 reference

12 December 2020

Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.

1 reference

12 December 2020

Influence of metabolites on protein binding of verapamil enantiomers

1 reference

12 December 2020

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

1 reference

12 December 2020

Stereoselective steady state disposition and action of propafenone in Chinese subjects

1 reference

12 December 2020

Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers

1 reference

12 December 2020

Active secretion and enterocytic drug metabolism barriers to drug absorption

1 reference

12 December 2020

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

1 reference

12 December 2020

Stereoselective pharmacokinetics of tocainide in human uraemic patients and in healthy subjects

1 reference

12 December 2020

Stereoselective disposition of mexiletine in man

1 reference

12 December 2020

Identification of P450 enzymes involved in metabolism of verapamil in humans

1 reference

12 December 2020

The influence of CYP2D6 activity on the kinetics of propafenone enantiomers in Chinese subjects

1 reference

12 December 2020

Interspecies differences in enantioselective mono-N-dealkylation of disopyramide by human and mouse liver microsomes

1 reference

12 December 2020

Genetically determined stereoselective excretion of encainide in humans and electrophysiologic effects of its enantiomers in canine cardiac Purkinje fibers

1 reference

12 December 2020

Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man

1 reference

12 December 2020

Stereoselective disposition and metabolism of disopyramide in pediatric patients

1 reference

12 December 2020

In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans: Comparison with in vivo data

1 reference

12 December 2020

The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias

1 reference

12 December 2020

Regiochemistry and enantioselectivity in the oxidative N-dealkylation of verapamil

1 reference

12 December 2020

Reliability of antiarrhythmic drug plasma concentration monitoring

1 reference

12 December 2020

Enantioselective steady-state kinetics of unbound disopyramide and its dealkylated metabolite in man

1 reference

12 December 2020

Stereoselective disposition and pharmacologic activity of propafenone enantiomers

1 reference

12 December 2020

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

1 reference

12 December 2020

Stereoselective effects of disopyramide enantiomers in humans

1 reference

12 December 2020

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

1 reference

12 December 2020

Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding

1 reference

12 December 2020

Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism

1 reference

12 December 2020

Enantioselective aspects of drug action and disposition: therapeutic pitfalls

1 reference

12 December 2020

Analysis and stereoselective metabolism after separate oral doses of tocainide enantiomers to healthy volunteers

1 reference

12 December 2020

The effect of food, time of dosing, and body position on the pharmacokinetics and pharmacodynamics of verapamil and norverapamil

1 reference

12 December 2020

Enantiomer specific pharmacokinetics

1 reference

12 December 2020

Input rate-dependent stereoselective pharmacokinetics. Experimental evidence in verapamil-infused isolated rat livers

1 reference

12 December 2020

Resolution and Electrophysiological Effects of Mexiletine Enantiomers

1 reference

12 December 2020

The pharmacokinetics of the enantiomers of mexiletine in humans

1 reference

12 December 2020

Enantioselective binding of propranolol, disopyramide, and verapamil to human alpha(1)-acid glycoprotein

1 reference

12 December 2020

Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines

1 reference

12 December 2020

Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance

1 reference

12 December 2020

Stereospecific salivary excretion of tocainide enantiomers in man.

1 reference

12 December 2020

Stereoselective pharmacokinetics of propafenone and its major metabolites in healthy Chinese volunteers

1 reference

12 December 2020

10.2165/00003088-200241080-00001

Identifiers

DOI

1 reference

Dimensions Publication ID

4 August 2017

1034165229

0 references

1 reference