(Q34726732)

4 August 2017

1 reference

title

Understanding the human condition: experimental strategies in mammalian genetics (English)

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4 August 2017

Kenneth Paigen

1

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4 August 2017

1 January 2002

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4 August 2017

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4 August 2017

43

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4 August 2017

3

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4 August 2017

123-135

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Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

4 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Challenges in small animal noninvasive imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Nuclear magnetic resonance spectroscopy and imaging in animal research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The influence of genetic background on the expression of the obese (ob) gene in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Introduction of a rabbit beta-globin gene into the mouse germ line

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetics of mouse behavior: interactions with laboratory environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The lac operator-repressor system is functional in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetics of native airway responsiveness in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Embryonic stem cells: An exciting field for basic research and tissue engineering, but also an ethical dilemma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A comprehensive genetic map of the mouse genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Ethical issues in embryonic stem cell research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

DNA arrays for analysis of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Comparative maps: the mammalian jigsaw puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Establishment in culture of pluripotential cells from mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

New seizure frequency QTL and the complex genetics of epilepsy in EL mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetic transformation of mouse embryos by microinjection of purified DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The significance of studies with transplanted tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Monitoring gene expression using DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

New approaches to phenotypic analysis in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The application of tissue microarrays to cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A major gene affecting age-related hearing loss in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Human embryonic stem cell technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Biochip technologies in cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Yeast microarrays for genome wide parallel genetic and gene expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Developmental potential of somatic stem cells in mammalian adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Chromosomal mapping of genes for epilepsy in NER: a rat strain with tonic-clonic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Control of memory formation through regulated expression of a CaMKII transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Spleen-Colony Formation in Anemic Mice of Genotype WW

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Modifier genes in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Sequence interpretation. Functional annotation of mouse genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Lengths of chromosomal segments conserved since divergence of man and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Interleukin 9: a candidate gene for asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Gene discovery using the serial analysis of gene expression technique: implications for cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

DNA chips: state-of-the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Maternal environment and genotype interact to establish diabesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The use of single nucleotide polymorphisms in the isolation of common disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Human embryonic stem cell research: ethical and legal issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

MyoD or Myf-5 is required for the formation of skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Magnetic resonance imaging of coronary arteries and heart valves in a living mouse: techniques and preliminary results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Proof of whole-cell implant in therapy of W-series anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genes involved in animal models of obesity and anorexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Mammalian cochlear genes and hereditary deafness

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Mouse models of blood pressure regulation and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

New prospects for human stem-cell therapy in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Functional screening of an asthma QTL in YAC transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Dissection of behavior and psychiatric disorders using the mouse as a model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Behavior and mutagenesis screens: the importance of baseline analysis of inbred strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Hypervariabflity of simple sequences as a general source for polymorphic DNA markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Multilineage cells from human adipose tissue: implications for cell-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Isolation of simple-sequence loci for use in polymerase chain reaction-based DNA fingerprinting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FILAR.43.3.123

21 January 2018

Identifiers

DOI

10.1093/ILAR.43.3.123

1 reference

4 August 2017

1 reference

PubMed ID

12105380