(Q34729807)

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Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo

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15 February 2020

Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo (English)

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15 February 2020

serous carcinoma

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based on heuristic

inferred from title

Uterine serous carcinoma

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based on heuristic

inferred from title

Salvatore Lopez

1

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15 February 2020

Elena Bonazzoli

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15 February 2020

Roberto Angioli

9

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15 February 2020

author name string

Carlton L Schwab

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15 February 2020

Emiliano Cocco

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15 February 2020

Stefania Bellone

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15 February 2020

Diana P English

6

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15 February 2020

Peter E Schwartz

7

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15 February 2020

Thomas Rutherford

8

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15 February 2020

Alessandro D Santin

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15 February 2020

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27 August 2014

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15 February 2020

Gynecologic Oncology

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15 February 2020

135

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15 February 2020

2

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15 February 2020

312-317

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15 February 2020

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

1 reference

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PI3K and cancer: lessons, challenges and opportunities

1 reference

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7 July 2018

New strategies in endometrial cancer: targeting the PI3K/mTOR pathway--the devil is in the details

1 reference

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7 July 2018

Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).

1 reference

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Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy

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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and ro

1 reference

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7 July 2018

Integrated genomic characterization of endometrial carcinoma

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HER2 expression beyond breast cancer: therapeutic implications for gynecologic malignancies

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

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Development of PI3K inhibitors: lessons learned from early clinical trials

1 reference

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7 July 2018

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

1 reference

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7 July 2018

Cancer statistics, 2013

1 reference

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Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

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7 July 2018

The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer

1 reference

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7 July 2018

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

1 reference

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7 July 2018

Use of mutation profiles to refine the classification of endometrial carcinomas.

1 reference

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7 July 2018

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

1 reference

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7 July 2018

A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas

1 reference

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7 July 2018

Emerging therapeutic targets in endometrial cancer

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7 July 2018

The PI3K pathway as drug target in human cancer

1 reference

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7 July 2018

Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270135

7 July 2018

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

1 reference

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

1 reference

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

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Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

1 reference

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

1 reference

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High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

1 reference

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7 July 2018

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7 July 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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1 reference

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1 reference

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Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Her-2/neu overexpression and amplification in uterine papillary serous carcinoma

1 reference

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1 reference

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Clinical significance of Her-2/neu overexpression in uterine serous carcinoma

1 reference

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1 reference

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10.1016/J.YGYNO.2014.08.024

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15 February 2020

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15 February 2020

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15 February 2020

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